2-(methylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Base Information

Chemical Name:2-(methylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione
CAS No.:1356352-97-0
Molecular Formula:C₁₆H₁₄F₃N₃O₃S
Molecular Weight:385.367
Hs Code.:

Synonyms:2-(methylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

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Chemical Property of 2-(methylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

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Technology Process of 2-(methylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

There total 6 articles about 2-(methylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356353-43-9
2-thioxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-2,3,5,6-tetrahydropyrido[2,3-d]pyrimidine-4,7(1H,8H)-dione

: 74-88-4
methyl iodide

: 1356352-97-0
2-(methylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Guidance literature:: With sodium hydrogencarbonate; In water; acetonitrile; at 50 ℃; for 0.5h;

Reference yield:

: 1356353-42-8
diethyl 2-carbamimidoylpentane-1,5-dioate

: 1356352-97-0
2-(methylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / Cooling with ice

1.2: 0.5 h / Cooling with ice

2.1: sodium hydrogencarbonate / water; acetonitrile / 0.5 h / 50 °C

With sodium hydride; sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1356352-97-0
2-(methylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

2.1: hydrogen; palladium 10% on activated carbon / water; methanol / 24 h / 20 °C

3.1: hydrogenchloride / water; tetrahydrofuran / 0.25 h / -5 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / Cooling with ice

4.2: 0.5 h / Cooling with ice

5.1: sodium hydrogencarbonate / water; acetonitrile / 0.5 h / 50 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydride; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;