1-[3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)phenyl]cyclopropane carbonitrile

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Chemical Name:1-[3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)phenyl]cyclopropane carbonitrile
CAS No.:1449515-06-3
Molecular Formula:C₁₉H₁₉N₅
Molecular Weight:317.393
Hs Code.:

Synonyms:1-[3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)phenyl]cyclopropane carbonitrile

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Chemical Property of 1-[3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)phenyl]cyclopropane carbonitrile

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Technology Process of 1-[3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)phenyl]cyclopropane carbonitrile

There total 8 articles about 1-[3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)phenyl]cyclopropane carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 607373-83-1
2-chloro-4-methoxy-5-nitro-pyridine

: 1449515-06-3
1-[3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)phenyl]cyclopropane carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 2 h / 20 °C

2: iron; acetic acid / 50 - 80 °C

3: orthoformic acid triethyl ester / 4 h / 100 °C

4: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 18 h / 110 °C

With palladium diacetate; iron; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; orthoformic acid triethyl ester; In tetrahydrofuran; toluene;

Reference yield:

: 1449516-02-2
1-(4-amino-3-ethylphenyl)cyclopropanecarbonitrile

: 7205-46-1
6-chloro-1-methyl-1H-imidazo[4,5-c]pyridine

: 1449515-06-3
1-[3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)phenyl]cyclopropane carbonitrile

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 110 ℃; for 18h;

Reference yield:

: 148582-37-0
5-bromo-1-ethyl-2-nitrobenzene

: 1449515-06-3
1-[3-ethyl-4-(1-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)phenyl]cyclopropane carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: zinc(II) fluoride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 5 h / 150 °C / Inert atmosphere; Microwave irradiation

2: tetrabutylammomium bromide; sodium hydroxide / water; acetonitrile / 2 h / 40 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 20 °C

4: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 18 h / 110 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc(II) fluoride; palladium 10% on activated carbon; tetrabutylammomium bromide; hydrogen; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;