methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)-3-(isopropylamino)biphenyl-4-carboxylate

Base Information

• Chemical Name: methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)-3-(isopropylamino)biphenyl-4-carboxylate
• CAS No.: 855478-14-7
• Molecular Formula: C₃₂H₄₀N₂O₅
• Molecular Weight: 532.68

Synonyms:methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)-3-(isopropylamino)biphenyl-4-carboxylate

Chemical Property of methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)-3-(isopropylamino)biphenyl-4-carboxylate

Chemical Property:

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Technology Process of methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)-3-(isopropylamino)biphenyl-4-carboxylate

There total 2 articles about methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)-3-(isopropylamino)biphenyl-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl [2-(4-bromophenyl)ethyl][(2R)-2-hydroxy-2-phenylethyl]carbamate (855482-71-2) + C17H26BNO4 → methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)-3-(isopropylamino)biphenyl-4-carboxylate (855478-14-7)

Guidance literature:

With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 70 ℃;

DOI:10.1021/jm701324c

Reference yield:

C27H32N2O3 + di-tert-butyl dicarbonate (24424-99-5) → methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)-3-(isopropylamino)biphenyl-4-carboxylate (855478-14-7)

Guidance literature:

In tetrahydrofuran; water; at 0 - 20 ℃; for 0.5h;

Reference yield:

methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)-3-(isopropylamino)biphenyl-4-carboxylate (855478-14-7) → C31H38N2O5

Guidance literature:

With sodium hydroxide; In ethanol; at 40 ℃;

DOI:10.1021/jm701324c

upstream raw materials:

di-tert-butyl dicarbonate

tert-butyl [2-(4-bromophenyl)ethyl][(2R)-2-hydroxy-2-phenylethyl]carbamate

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