tert-butyl [2-(4-bromophenyl)ethyl][(2R)-2-hydroxy-2-phenylethyl]carbamate

Base Information

• Chemical Name: tert-butyl [2-(4-bromophenyl)ethyl][(2R)-2-hydroxy-2-phenylethyl]carbamate
• CAS No.: 855482-71-2
• Molecular Formula: C₂₁H₂₆BrNO₃
• Molecular Weight: 420.346

Synonyms:tert-butyl [2-(4-bromophenyl)ethyl][(2R)-2-hydroxy-2-phenylethyl]carbamate

Chemical Property of tert-butyl [2-(4-bromophenyl)ethyl][(2R)-2-hydroxy-2-phenylethyl]carbamate

Chemical Property:

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Technology Process of tert-butyl [2-(4-bromophenyl)ethyl][(2R)-2-hydroxy-2-phenylethyl]carbamate

There total 1 articles about tert-butyl [2-(4-bromophenyl)ethyl][(2R)-2-hydroxy-2-phenylethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(1R)-2-{[2-(4-bromophenyl)ethyl]amino}-1-phenylethanol hydrochloride (1016313-22-6) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl [2-(4-bromophenyl)ethyl][(2R)-2-hydroxy-2-phenylethyl]carbamate (855482-71-2)

Guidance literature:

With sodium hydroxide; at 20 ℃; for 1h; pH=7 - 8;

DOI:10.1021/jm701324c

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) + tert-butyl [2-(4-bromophenyl)ethyl][(2R)-2-hydroxy-2-phenylethyl]carbamate (855482-71-2) → tert-butyl [2-(4-bromophenyl)ethyl][(2R)-2-phenyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]carbamate (855481-88-8)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

tert-butyl [2-(4-bromophenyl)ethyl][(2R)-2-hydroxy-2-phenylethyl]carbamate (855482-71-2) + [3-isobutyl-4-(methoxycarbonyl)phenyl]boronic acid (855482-81-4) → C33H41NO5

Guidance literature:

With sodium carbonate; Ph(PPh₃)4; In 1,2-dimethoxyethane; at 70 ℃;

DOI:10.1021/jm701324c

upstream raw materials:

(1R)-2-{[2-(4-bromophenyl)ethyl]amino}-1-phenylethanol hydrochloride

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl [2-(4-bromophenyl)ethyl][(2R)-2-phenyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]carbamate

methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)-3-(isopropylsulfanyl)biphenyl-4-carboxylate

methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)-3-(tetrahydro-9H-pyran-4-yloxy)biphenyl-4-carboxylate

methyl 4'-(2-{(tert-butoxycarbonyl)[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)-3-(isopropylamino)biphenyl-4-carboxylate

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