Acetic acid (2R,4aR,6S,7R,8S,8aR)-8-acetoxy-6-[(2R,3R,4S,5R,6R)-4,5-bis-(4-methoxy-benzyloxy)-6-(4-methoxy-benzyloxymethyl)-2-((S)-1-methyl-dec-8-ynyloxy)-tetrahydro-pyran-3-yloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester

Base Information

Chemical Name:Acetic acid (2R,4aR,6S,7R,8S,8aR)-8-acetoxy-6-[(2R,3R,4S,5R,6R)-4,5-bis-(4-methoxy-benzyloxy)-6-(4-methoxy-benzyloxymethyl)-2-((S)-1-methyl-dec-8-ynyloxy)-tetrahydro-pyran-3-yloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester
CAS No.:316790-26-8
Molecular Formula:C₅₉H₇₄O₁₇
Molecular Weight:1055.23
Hs Code.:

Acetic acid (2R,4aR,6S,7R,8S,8aR)-8-acetoxy-6-[(2R,3R,4S,5R,6R)-4,5-bis-(4-methoxy-benzyloxy)-6-(4-methoxy-benzyloxymethyl)-2-((S)-1-methyl-dec-8-ynyloxy)-tetrahydro-pyran-3-yloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester

Synonyms:Acetic acid (2R,4aR,6S,7R,8S,8aR)-8-acetoxy-6-[(2R,3R,4S,5R,6R)-4,5-bis-(4-methoxy-benzyloxy)-6-(4-methoxy-benzyloxymethyl)-2-((S)-1-methyl-dec-8-ynyloxy)-tetrahydro-pyran-3-yloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester

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Chemical Property of Acetic acid (2R,4aR,6S,7R,8S,8aR)-8-acetoxy-6-[(2R,3R,4S,5R,6R)-4,5-bis-(4-methoxy-benzyloxy)-6-(4-methoxy-benzyloxymethyl)-2-((S)-1-methyl-dec-8-ynyloxy)-tetrahydro-pyran-3-yloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester

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Technology Process of Acetic acid (2R,4aR,6S,7R,8S,8aR)-8-acetoxy-6-[(2R,3R,4S,5R,6R)-4,5-bis-(4-methoxy-benzyloxy)-6-(4-methoxy-benzyloxymethyl)-2-((S)-1-methyl-dec-8-ynyloxy)-tetrahydro-pyran-3-yloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester

There total 8 articles about Acetic acid (2R,4aR,6S,7R,8S,8aR)-8-acetoxy-6-[(2R,3R,4S,5R,6R)-4,5-bis-(4-methoxy-benzyloxy)-6-(4-methoxy-benzyloxymethyl)-2-((S)-1-methyl-dec-8-ynyloxy)-tetrahydro-pyran-3-yloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 316790-25-7
2,3-di-O-acetyl-4,6-O-(p-methoxybenzylidene)-α-D-glucopyranosyl bromide

: 316790-21-3
[(10S)-2-undecyn-10-yl]-3,4,6-tri-O-(p-methoxybenzyl)-β-D-glucopyranoside

: 316790-26-8
Acetic acid (2R,4aR,6S,7R,8S,8aR)-8-acetoxy-6-[(2R,3R,4S,5R,6R)-4,5-bis-(4-methoxy-benzyloxy)-6-(4-methoxy-benzyloxymethyl)-2-((S)-1-methyl-dec-8-ynyloxy)-tetrahydro-pyran-3-yloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester

Guidance literature:: With 2,6-di-tert-butyl-pyridine; 4 A molecular sieve; silver trifluoromethanesulfonate; In dichloromethane; at -5 ℃; for 3h;
DOI:10.1021/jo0012952

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 316790-26-8
Acetic acid (2R,4aR,6S,7R,8S,8aR)-8-acetoxy-6-[(2R,3R,4S,5R,6R)-4,5-bis-(4-methoxy-benzyloxy)-6-(4-methoxy-benzyloxymethyl)-2-((S)-1-methyl-dec-8-ynyloxy)-tetrahydro-pyran-3-yloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide / 0.5 h / 0 °C

1.2: 76 percent / (n-Bu)4NI / dimethylformamide / 0 h / 20 °C

2.1: dimethyldioxirane / CH₂Cl₂; acetone / -25 °C

3.1: 95 mg / ZnCl₂ / tetrahydrofuran / 14 h / 20 °C

4.1: 89 percent / AgOTf; 2,6-di-tert-butylpyridine; 4 Angstroem molecular sieves / CH₂Cl₂ / 3 h / -5 °C

With 2,6-di-tert-butyl-pyridine; 4 A molecular sieve; silver trifluoromethanesulfonate; 3,3-dimethyldioxirane; sodium hydride; zinc(II) chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; 4.1: Koenigs-Knorr reaction;
DOI:10.1021/jo0012952

Reference yield:

: 13265-84-4
D-glucal

: 316790-26-8
Acetic acid (2R,4aR,6S,7R,8S,8aR)-8-acetoxy-6-[(2R,3R,4S,5R,6R)-4,5-bis-(4-methoxy-benzyloxy)-6-(4-methoxy-benzyloxymethyl)-2-((S)-1-methyl-dec-8-ynyloxy)-tetrahydro-pyran-3-yloxy]-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide / 0.5 h / 0 °C

1.2: 76 percent / (n-Bu)4NI / dimethylformamide / 0 h / 20 °C

2.1: dimethyldioxirane / CH₂Cl₂; acetone / -25 °C

3.1: 95 mg / ZnCl₂ / tetrahydrofuran / 14 h / 20 °C

4.1: 89 percent / AgOTf; 2,6-di-tert-butylpyridine; 4 Angstroem molecular sieves / CH₂Cl₂ / 3 h / -5 °C

With 2,6-di-tert-butyl-pyridine; 4 A molecular sieve; silver trifluoromethanesulfonate; 3,3-dimethyldioxirane; sodium hydride; zinc(II) chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; 4.1: Koenigs-Knorr reaction;
DOI:10.1021/jo0012952