8β-((benzoyloxy)methyl)-1β-methoxy-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one

Base Information

• Chemical Name: 8β-((benzoyloxy)methyl)-1β-methoxy-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one
• CAS No.: 123834-76-4
• Molecular Formula: C₂₈H₃₃F₃O₆
• Molecular Weight: 522.562
• Mol file: 123834-76-4.mol

Synonyms:8β-((benzoyloxy)methyl)-1β-methoxy-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one

Chemical Property of 8β-((benzoyloxy)methyl)-1β-methoxy-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8β-((benzoyloxy)methyl)-1β-methoxy-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one

There total 1 articles about 8β-((benzoyloxy)methyl)-1β-methoxy-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(3R,3aS,6aR,7aR,11aS,11bR,11cS)-5-Ethoxy-10-methoxy-3,11a,11c-trimethyl-3a,4,5,6a,7,7a,8,11a,11b,11c-decahydro-1H,3H-6-oxa-benzo[de]anthracene-2,11-dione (123834-69-5,123835-01-8) + trifluoroacetic anhydride (407-25-0) → 8β-((benzoyloxy)methyl)-1β-methoxy-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one (123834-76-4)

Guidance literature:

With pyridine; at -20 ℃; for 1h;

DOI:10.1021/jo00289a023

Reference yield: 92.0%

8β-((benzoyloxy)methyl)-1β-methoxy-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one (123834-76-4) → 8β-((benzoyloxy)methyl)-1β-hydroxy-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one (123834-77-5)

Guidance literature:

With chloro-trimethyl-silane; sodium iodide; In acetonitrile; at 25 ℃; for 20h;

DOI:10.1021/jo00289a023

Reference yield:

8β-((benzoyloxy)methyl)-1β-methoxy-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one (123834-76-4) → 1β-acetoxy-8β-((benzoyloxy)methyl)-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one (123834-78-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / Me₃SiCl, NaI / acetonitrile / 20 h / 25 °C

2: 84 percent / pyridine / 18 h / 25 °C

With pyridine; chloro-trimethyl-silane; sodium iodide; In acetonitrile;

DOI:10.1021/jo00289a023

upstream raw materials:

(3R,3aS,6aR,7aR,11aS,11bR,11cS)-5-Ethoxy-10-methoxy-3,11a,11c-trimethyl-3a,4,5,6a,7,7a,8,11a,11b,11c-decahydro-1H,3H-6-oxa-benzo[de]anthracene-2,11-dione

trifluoroacetic anhydride

Downstream raw materials:

8β-((benzoyloxy)methyl)-1β-hydroxy-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one

1β-acetoxy-8β-((benzoyloxy)methyl)-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one