1β-acetoxy-8β-((benzoyloxy)methyl)-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one

Base Information

• Chemical Name: 1β-acetoxy-8β-((benzoyloxy)methyl)-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one
• CAS No.: 123834-78-6
• Molecular Formula: C₂₉H₃₃F₃O₇
• Molecular Weight: 550.572
• Mol file: 123834-78-6.mol

Synonyms:1β-acetoxy-8β-((benzoyloxy)methyl)-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one

Chemical Property of 1β-acetoxy-8β-((benzoyloxy)methyl)-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1β-acetoxy-8β-((benzoyloxy)methyl)-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one

There total 2 articles about 1β-acetoxy-8β-((benzoyloxy)methyl)-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

8β-((benzoyloxy)methyl)-1β-hydroxy-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one (123834-77-5) + acetic anhydride (108-24-7) → 1β-acetoxy-8β-((benzoyloxy)methyl)-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one (123834-78-6)

Guidance literature:

With pyridine; at 25 ℃; for 18h;

DOI:10.1021/jo00289a023

Reference yield:

8β-((benzoyloxy)methyl)-1β-methoxy-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one (123834-76-4) → 1β-acetoxy-8β-((benzoyloxy)methyl)-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one (123834-78-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / Me₃SiCl, NaI / acetonitrile / 20 h / 25 °C

2: 84 percent / pyridine / 18 h / 25 °C

With pyridine; chloro-trimethyl-silane; sodium iodide; In acetonitrile;

DOI:10.1021/jo00289a023

Reference yield: 89.0%

Mangantriacetat + 1β-acetoxy-8β-((benzoyloxy)methyl)-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one (123834-78-6) → 8β-((benzoyloxy)methyl)-1β,11β-diacetoxy-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one (123834-79-7)

Guidance literature:

In benzene; for 15h; Heating;

DOI:10.1021/jo00289a023

upstream raw materials:

8β-((benzoyloxy)methyl)-1β-hydroxy-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one

acetic anhydride

8β-((benzoyloxy)methyl)-1β-methoxy-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one

Downstream raw materials:

8β-((benzoyloxy)methyl)-1β,11β-diacetoxy-13-methyl-7α-(trifluoroacetoxy)-19-nor-9β-podocarp-13-en-12-one