7-(2-C-methyl-β-D-ribofuranosyl)-4-(phenyl)-7H-pyrrolo[2,3-d]pyrimidine

Base Information

Chemical Name:7-(2-C-methyl-β-D-ribofuranosyl)-4-(phenyl)-7H-pyrrolo[2,3-d]pyrimidine
CAS No.:1338072-46-0
Molecular Formula:C₁₈H₁₉N₃O₄
Molecular Weight:341.367
Hs Code.:

Synonyms:7-(2-C-methyl-β-D-ribofuranosyl)-4-(phenyl)-7H-pyrrolo[2,3-d]pyrimidine

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Chemical Property of 7-(2-C-methyl-β-D-ribofuranosyl)-4-(phenyl)-7H-pyrrolo[2,3-d]pyrimidine

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Technology Process of 7-(2-C-methyl-β-D-ribofuranosyl)-4-(phenyl)-7H-pyrrolo[2,3-d]pyrimidine

There total 4 articles about 7-(2-C-methyl-β-D-ribofuranosyl)-4-(phenyl)-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 98-80-6
phenylboronic acid

: 443642-33-9
4-chloro-7-[2-C-methyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine

: 1338072-46-0
7-(2-C-methyl-β-D-ribofuranosyl)-4-(phenyl)-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: With trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate; In water; acetonitrile; at 100 ℃; for 3h; Inert atmosphere;
DOI:10.1135/cccc2011082

Reference yield:

: 741686-50-0
1,2-anhydro-3,5-di-O-(4-methylbenzoyl)-2-C-methyl-β-D-ribofuranose

: 1338072-46-0
7-(2-C-methyl-β-D-ribofuranosyl)-4-(phenyl)-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere

1.2: 18 h / 20 °C

2.1: methanol; ammonia / 24 h / 20 °C

3.1: trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate / water; acetonitrile / 3 h / 100 °C / Inert atmosphere

With methanol; trisodium tris(3-sulfophenyl)phosphine; ammonia; palladium diacetate; sodium hydride; sodium carbonate; In water; N,N-dimethyl-formamide; acetonitrile; mineral oil; 3.1: Suzuki-Myiaura reaction;
DOI:10.1135/cccc2011082

Reference yield:

: 943638-20-8
2-C-methyl-3,5-di-O-(4-methylbenzoyl)-D-ribofuranose

: 1338072-46-0
7-(2-C-methyl-β-D-ribofuranosyl)-4-(phenyl)-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanesulfonyl chloride; triethylamine / dichloromethane / 1.33 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere

2.2: 18 h / 20 °C

3.1: methanol; ammonia / 24 h / 20 °C

4.1: trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate / water; acetonitrile / 3 h / 100 °C / Inert atmosphere

With methanol; trisodium tris(3-sulfophenyl)phosphine; ammonia; palladium diacetate; sodium hydride; sodium carbonate; methanesulfonyl chloride; triethylamine; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil; 4.1: Suzuki-Myiaura reaction;
DOI:10.1135/cccc2011082