443642-33-9

Basic information

• Product Name: 4-Chloro-7-(2-C-methyl-beta-D-ribofuranosyl)-7H-Pyrrolo[2,3-d]pyrimidine
• Synonyms: 4-Chloro-7-(2-C-methyl-beta-D-ribofuranosyl)-7H-Pyrrolo[2,3-d]pyrimidine;4-Chloro-7-(2--C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d] pyrimidine;4-Chloro-7-(2-C-methyl-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
• CAS NO: 443642-33-9
• Molecular Formula: C₁₂H₁₄ClN₃O₄
• Molecular Weight: 299.71026
• Mol File: 443642-33-9.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Chloro-7-(2-C-methyl-beta-D-ribofuranosyl)-7H-Pyrrolo[2,3-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-7-(2-C-methyl-beta-D-ribofuranosyl)-7H-Pyrrolo[2,3-d]pyrimidine(443642-33-9)
• EPA Substance Registry System: 4-Chloro-7-(2-C-methyl-beta-D-ribofuranosyl)-7H-Pyrrolo[2,3-d]pyrimidine(443642-33-9)

Safety Data

• Hazardous Substances Data: 443642-33-9(Hazardous Substances Data)

Usage

General Description

4-Chloro-7-(2-C-methyl-beta-D-ribofuranosyl)-7H-Pyrrolo[2,3-d]pyrimidine is a synthetic chemical compound that belongs to the class of pyrrolopyrimidine nucleosides. It is a modified form of the nucleoside cytidine, with a chlorine atom attached to the 4th carbon position and a 2-C-methyl-beta-D-ribofuranosyl group. 4-Chloro-7-(2-C-methyl-beta-D-ribofuranosyl)-7H-Pyrrolo[2,3-d]pyrimidine has shown potential biological activity as an antiviral agent, particularly against the hepatitis C virus. Its modified structure allows it to interact with viral polymerases and inhibit viral replication. Additionally, it has also been studied for its potential anticancer properties, with some research suggesting it may interfere with cancer cell growth and proliferation. Overall, 4-Chloro-7-(2-C-methyl-beta-D-ribofuranosyl)-7H-Pyrrolo[2,3-d]pyrimidine is a promising chemical compound with potential therapeutic applications in antiviral and anticancer drug development.

Upstream product

• 443642-32-8 4-chloro-7-[3,5-bis-O-(2,4-dichlorophenylmethyl)-2-C-methyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine 

Downstream Products

• 443642-29-3 7-deaza-2'-C-methyl-adenosine 
• 1338072-46-0 7-(2-C-methyl-β-D-ribofuranosyl)-4-(phenyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 443642-47-5 4-amino-5-bromo-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 443642-46-4 4-amino-5-chloro-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine 

Relevant articles and documents

NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYERMASE

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

5-nitro-nucleoside compounds for treating viral infections

Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus.

Oligonucleotides having modified nucleoside units

Disclosed are oligonucleotide that include one or more modified nucleoside units. The oligonucleotides are particularly useful as antisense agents, ribozymes, aptamer, siRNA agents, probes and primers or, when hybridized to an RNA, as a substrate for RNA cleaving enzymes including RNase H and dsRNase.