4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoyl fluoride

Base Information

Chemical Name:4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoyl fluoride
CAS No.:871339-77-4
Molecular Formula:C₂₂H₂₅F₇N₄O₃
Molecular Weight:526.454
Hs Code.:

Synonyms:4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoyl fluoride

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Chemical Property of 4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoyl fluoride

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Technology Process of 4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoyl fluoride

There total 6 articles about 4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 871339-76-3
4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoic acid

: 871339-77-4
4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoyl fluoride

Guidance literature:: With pyridine; trifluoro-[1,3,5]triazine; In dichloromethane; at 0 ℃; for 2.5h;

Reference yield:

: 871339-72-9
phenylmethyl 3,5-dibromo-4-methylbenzoate

: 871339-77-4
4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoyl fluoride

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 100 °C

2.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 100 °C

3.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

3.2: 1.5 h / 0 - 20 °C

4.1: hydrogen / palladium 10% on activated carbon / 3 h

5.1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 2.5 h / 0 °C

With pyridine; trifluoro-[1,3,5]triazine; hydrogen; caesium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In dichloromethane; toluene;

Reference yield:

: 871339-73-0
1,1-dimethylethyl 4-(3-bromo-2-methyl-5-{[(phenylmethyl)oxy]carbonyl}phenyl)piperazine-1-carboxylate

: 871339-77-4
4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoyl fluoride

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 100 °C

2.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

2.2: 1.5 h / 0 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / 3 h

4.1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 2.5 h / 0 °C

With pyridine; trifluoro-[1,3,5]triazine; hydrogen; caesium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In dichloromethane; toluene;