[4-(6-isopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazin-1-yl]-(1-phenyl-1H-[1,2,4]triazol-3-yl)-methanone

Base Information

Chemical Name:[4-(6-isopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazin-1-yl]-(1-phenyl-1H-[1,2,4]triazol-3-yl)-methanone
CAS No.:1443757-81-0
Molecular Formula:C₂₄H₂₈N₆O₂
Molecular Weight:432.525
Hs Code.:

Synonyms:[4-(6-isopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazin-1-yl]-(1-phenyl-1H-[1,2,4]triazol-3-yl)-methanone

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Chemical Property of [4-(6-isopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazin-1-yl]-(1-phenyl-1H-[1,2,4]triazol-3-yl)-methanone

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Technology Process of [4-(6-isopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazin-1-yl]-(1-phenyl-1H-[1,2,4]triazol-3-yl)-methanone

There total 11 articles about [4-(6-isopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazin-1-yl]-(1-phenyl-1H-[1,2,4]triazol-3-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 24036-63-3
1-phenyl-1H-[1,2,4]triazole-3-carboxylic acid

: 1443759-05-4
(3,3-dimethyl-piperazin-1-yl)-(6-isopropyl-pyridin-2-yl)-methanone trifluoroacetate

: 1443757-81-0
[4-(6-isopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazin-1-yl]-(1-phenyl-1H-[1,2,4]triazol-3-yl)-methanone

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 62-53-3
aniline

: 1443757-81-0
[4-(6-isopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazin-1-yl]-(1-phenyl-1H-[1,2,4]triazol-3-yl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium nitrite; tetrafluoroboric acid / water / 1 h / 0 °C

1.2: 20 °C / Cooling with ice

1.3: 48 h

2.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C

With tetrafluoroboric acid; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium nitrite; In water; N,N-dimethyl-formamide;

Reference yield:

: 98-80-6
phenylboronic acid

: 1443757-81-0
[4-(6-isopropyl-pyridine-2-carbonyl)-2,2-dimethyl-piperazin-1-yl]-(1-phenyl-1H-[1,2,4]triazol-3-yl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; copper diacetate / dichloromethane / 72 h / 20 °C

1.2: 20 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C

With pyridine; copper diacetate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;