Technology Process of 2',3,3''-triBoc-1-(N-Boc-3-amino-2(S)-hydroxy-propionyl)-sisomicin
There total 9 articles about 2',3,3''-triBoc-1-(N-Boc-3-amino-2(S)-hydroxy-propionyl)-sisomicin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium dithionite; water; sodium hydroxide;
In
ethanol;
at 70 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 4-methyl-morpholine / 1,4-dioxane; water / 0 - 20 °C
2: N-hydroxy-5-norbomene-2,3-dicarboxylic acid imide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h
3: sodium dithionite; water; sodium hydroxide / ethanol / 12 h / 70 °C
With
4-methyl-morpholine; sodium dithionite; water; N-hydroxy-5-norbomene-2,3-dicarboxylic acid imide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide;
In
1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: zinc diacetate / methanol / 1 h
2: zinc diacetate / methanol / 1 h
3: tetrahydrofuran / 2.5 h
4: 4-methyl-morpholine / tetrahydrofuran / 3 h
5: 2,2',2''-triaminotriethylamine / dichloromethane / 0.75 h
6: N-hydroxy-5-norbomene-2,3-dicarboxylic acid imide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h
7: sodium dithionite; water; sodium hydroxide / ethanol / 12 h / 70 °C
With
4-methyl-morpholine; sodium dithionite; 2,2',2''-triaminotriethylamine; zinc diacetate; water; N-hydroxy-5-norbomene-2,3-dicarboxylic acid imide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
