(3S,5S)-5-methyl-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Base Information

Chemical Name:(3S,5S)-5-methyl-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine
CAS No.:503843-29-6
Molecular Formula:C₁₄H₁₉NO
Molecular Weight:217.311
Hs Code.:

Synonyms:(3S,5S)-5-methyl-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Suppliers and Price of (3S,5S)-5-methyl-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (3S,5S)-5-methyl-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (3S,5S)-5-methyl-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

There total 2 articles about (3S,5S)-5-methyl-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 173173-75-6
(S)-1-((S)-2-Hydroxy-1-phenyl-ethyl)-6-methyl-piperidin-2-one

: 503843-29-6
(3S,5S)-5-methyl-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene; at -78 ℃;
DOI:10.1021/jo0266083

Reference yield:

: 176778-23-7
(3S,8aR)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

: 503843-29-6
(3S,5S)-5-methyl-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: CuCN; BF₃*Et₂O / diethyl ether; tetrahydrofuran

2: Red-Al / tetrahydrofuran; toluene / -78 °C

With boron trifluoride diethyl etherate; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1021/jo0266083

Reference yield: 75.0%

: 128957-79-9
2-butyl-2-ethynyl-1,3-dioxolane

: 503843-29-6
(3S,5S)-5-methyl-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

: 503843-24-1
(2S,6S)-2-[(2-butyl-1,3-dioxolan-2-yl)ethynyl]-1-[(1S)-2-hydroxy-1-phenylethyl]-6-methylpiperidine

Guidance literature:: 2-butyl-2-ethynyl-1,3-dioxolane; With ethylmagnesium bromide; In tetrahydrofuran; at 0 ℃; for 0.5h;

(3S,5S)-5-methyl-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine; In tetrahydrofuran; at 0 - 20 ℃; for 14h; Further stages.;
DOI:10.1021/jo0266083