Technology Process of (E)-tert-butyl 4-[2-(6-cyano-2-naphthyl)vinyl]phenoxyacetate
There total 7 articles about (E)-tert-butyl 4-[2-(6-cyano-2-naphthyl)vinyl]phenoxyacetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 23 ℃;
for 19h;
DOI:10.1248/cpb.47.1685
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 1,3-dimethyl-2-imidazolidione / 3 h / 160 °C
2.1: 72 percent / pyridine / 15 h / 23 °C
3.1: Pd(PPh3)2Cl2; LiCl; 2,6-di-tert-butyl-4-methylphenol / dimethylformamide / 2.5 h / 70 °C
3.2: 93 percent / aq. KF / diethyl ether / 3 h / 23 °C
4.1: 84 percent / OsO4; aq. NaIO4 / dioxane / 18 h / 23 °C
5.1: n-BuLi / benzene; hexane / 2 h / 23 °C
5.2: 703 mg / 4.5 h / 23 °C
6.1: AlCl3; NaI / acetonitrile; CH2Cl2 / 23 h / Heating
7.1: 79 percent / K2CO3 / dimethylformamide / 19 h / 23 °C
With
pyridine; 1,3-dimethyl-2-imidazolidinone; bis-triphenylphosphine-palladium(II) chloride; sodium periodate; osmium(VIII) oxide; n-butyllithium; aluminium trichloride; 2,6-di-tert-butyl-4-methyl-phenol; potassium carbonate; sodium iodide; lithium chloride;
In
1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; benzene;
1.1: Substitution / 2.1: Substitution / 3.1: Substitution / 3.2: Substitution / 4.1: Oxidation / 5.1: Elimination / 5.2: Wittig reaction / 6.1: demethylation / 7.1: Condensation;
DOI:10.1248/cpb.47.1685
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 72 percent / pyridine / 15 h / 23 °C
2.1: Pd(PPh3)2Cl2; LiCl; 2,6-di-tert-butyl-4-methylphenol / dimethylformamide / 2.5 h / 70 °C
2.2: 93 percent / aq. KF / diethyl ether / 3 h / 23 °C
3.1: 84 percent / OsO4; aq. NaIO4 / dioxane / 18 h / 23 °C
4.1: n-BuLi / benzene; hexane / 2 h / 23 °C
4.2: 703 mg / 4.5 h / 23 °C
5.1: AlCl3; NaI / acetonitrile; CH2Cl2 / 23 h / Heating
6.1: 79 percent / K2CO3 / dimethylformamide / 19 h / 23 °C
With
pyridine; bis-triphenylphosphine-palladium(II) chloride; sodium periodate; osmium(VIII) oxide; n-butyllithium; aluminium trichloride; 2,6-di-tert-butyl-4-methyl-phenol; potassium carbonate; sodium iodide; lithium chloride;
In
1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; benzene;
1.1: Substitution / 2.1: Substitution / 2.2: Substitution / 3.1: Oxidation / 4.1: Elimination / 4.2: Wittig reaction / 5.1: demethylation / 6.1: Condensation;
DOI:10.1248/cpb.47.1685
