52927-22-7 Usage
Description
6-Cyano-2-naphthol (6CN2) is an aromatic alcohol synthesized from 6-bromo-2-naphthol. It is characterized as a superphotoacid with a ground state pKa value of 8.4 and an excited state pKa value of 0.2. This brown crystalline solid has the unique ability to protonate PANI-ES (polyaniline emeraldine salt) to form PANI-EB (emeraldine base), which exhibits enhanced conductivity. The chemical properties and photophysical behavior of 6CN2 have been extensively studied, making it a compound of interest in various applications.
Uses
Used in Pharmaceutical Industry:
6-Cyano-2-naphthol is used as an intermediate for the synthesis of Nafamostat mesilate (N210000), a drug with various therapeutic applications.
Used in Chemical Synthesis:
6-Cyano-2-naphthol serves as a reactant in several important chemical reactions, including palladium-catalyzed reduction, nickel-catalyzed cross-coupling reactions, and palladium-catalyzed Heck reactions. These reactions are crucial for the synthesis of various complex organic compounds and materials.
Used in Material Science:
Due to its unique photophysical properties, 6-Cyano-2-naphthol can be utilized in the development of advanced materials with enhanced conductivity and optical properties, particularly in the field of organic electronics and photovoltaics.
Check Digit Verification of cas no
The CAS Registry Mumber 52927-22-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,9,2 and 7 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 52927-22:
(7*5)+(6*2)+(5*9)+(4*2)+(3*7)+(2*2)+(1*2)=127
127 % 10 = 7
So 52927-22-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H7NO/c12-7-8-1-2-10-6-11(13)4-3-9(10)5-8/h1-6,13H
52927-22-7Relevant articles and documents
Decarboxylative Hydroxylation of Benzoic Acids
Ritter, Tobias,Su, Wanqi,Xu, Peng
, p. 24012 - 24017 (2021/10/06)
Herein, we report the first decarboxylative hydroxylation to synthesize phenols from benzoic acids at 35 °C via photoinduced ligand-to-metal charge transfer (LMCT)-enabled radical decarboxylative carbometalation. The aromatic decarboxylative hydroxylation is synthetically promising due to its mild conditions, broad substrate scope, and late-stage applications.
Process for Preparing Nafamostat Mesilate and Intermediate Thereof
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Paragraph 0080-0081, (2021/10/27)
The present invention provides a method for efficiently producing astaxmostat mesylate through a simple process and a method for producing 6 - amidino -2 - naphthol mesylate in high yield under mild conditions.
C -Glycosylation of Substituted β-Naphthols with Trichloroacetimidate Glycosyl Donors
Chakraborty, Soumen,Mal, Dipakranjan
, p. 1560 - 1568 (2018/01/17)
Several glycosyl donors have been systematically investigated for C-glycosylation of substituted β-naphthols to delineate the effect of the substituents. Whereas glycosylations of the parent 2-naphthol are smoothly achievable, those of differently substituted 2-naphthols are cumbersome. Efficiency of the glycosylation depends on the nature of both the glycosyl donors and the substituents of the arene ring. Among various glycosyl donors, trichloroacetimidate glycosyl donors are found to be superior for glycosylation with substituted 2-naphthols.