4-(4-formyl-phenoxy)-butyric acid 2-(2-benzyloxycarbonyl-3-{3-[4-(4-formyl-phenoxy)-butyryloxy]-2-[4-(4-formyl-phenoxy)-butyryloxymethyl]-2-methyl-propionyloxy}-2-methyl-propoxycarbonyl)-3-[4-(4-formyl-phenoxy)-butyryloxy]-2-methyl-propyl ester

Base Information

• Chemical Name: 4-(4-formyl-phenoxy)-butyric acid 2-(2-benzyloxycarbonyl-3-{3-[4-(4-formyl-phenoxy)-butyryloxy]-2-[4-(4-formyl-phenoxy)-butyryloxymethyl]-2-methyl-propionyloxy}-2-methyl-propoxycarbonyl)-3-[4-(4-formyl-phenoxy)-butyryloxy]-2-methyl-propyl ester
• CAS No.: 364780-65-4
• Molecular Formula: C₆₆H₇₂O₂₂
• Molecular Weight: 1217.28

Synonyms:4-(4-formyl-phenoxy)-butyric acid 2-(2-benzyloxycarbonyl-3-{3-[4-(4-formyl-phenoxy)-butyryloxy]-2-[4-(4-formyl-phenoxy)-butyryloxymethyl]-2-methyl-propionyloxy}-2-methyl-propoxycarbonyl)-3-[4-(4-formyl-phenoxy)-butyryloxy]-2-methyl-propyl ester

Chemical Property of 4-(4-formyl-phenoxy)-butyric acid 2-(2-benzyloxycarbonyl-3-{3-[4-(4-formyl-phenoxy)-butyryloxy]-2-[4-(4-formyl-phenoxy)-butyryloxymethyl]-2-methyl-propionyloxy}-2-methyl-propoxycarbonyl)-3-[4-(4-formyl-phenoxy)-butyryloxy]-2-methyl-propyl ester

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Technology Process of 4-(4-formyl-phenoxy)-butyric acid 2-(2-benzyloxycarbonyl-3-{3-[4-(4-formyl-phenoxy)-butyryloxy]-2-[4-(4-formyl-phenoxy)-butyryloxymethyl]-2-methyl-propionyloxy}-2-methyl-propoxycarbonyl)-3-[4-(4-formyl-phenoxy)-butyryloxy]-2-methyl-propyl ester

There total 4 articles about 4-(4-formyl-phenoxy)-butyric acid 2-(2-benzyloxycarbonyl-3-{3-[4-(4-formyl-phenoxy)-butyryloxy]-2-[4-(4-formyl-phenoxy)-butyryloxymethyl]-2-methyl-propionyloxy}-2-methyl-propoxycarbonyl)-3-[4-(4-formyl-phenoxy)-butyryloxy]-2-methyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) + 4-bromo-butyric acid 2-{2-benzyloxycarbonyl-3-[3-(4-bromo-butyryloxy)-2-(4-bromo-butyryloxymethyl)-2-methyl-propionyloxy]-2-methyl-propoxycarbonyl}-3-(4-bromo-butyryloxy)-2-methyl-propyl ester (364780-64-3) → 4-(4-formyl-phenoxy)-butyric acid 2-(2-benzyloxycarbonyl-3-{3-[4-(4-formyl-phenoxy)-butyryloxy]-2-[4-(4-formyl-phenoxy)-butyryloxymethyl]-2-methyl-propionyloxy}-2-methyl-propoxycarbonyl)-3-[4-(4-formyl-phenoxy)-butyryloxy]-2-methyl-propyl ester (364780-65-4)

Guidance literature:

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 75 ℃; for 48h;

DOI:10.1021/ja001819f

Reference yield:

2,2-bis(hydroxymethyl)propionic acid (4767-03-7) → 4-(4-formyl-phenoxy)-butyric acid 2-(2-benzyloxycarbonyl-3-{3-[4-(4-formyl-phenoxy)-butyryloxy]-2-[4-(4-formyl-phenoxy)-butyryloxymethyl]-2-methyl-propionyloxy}-2-methyl-propoxycarbonyl)-3-[4-(4-formyl-phenoxy)-butyryloxy]-2-methyl-propyl ester (364780-65-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: KOH / dimethylformamide / 1 h / 100 °C

1.2: 60 percent / dimethylformamide / 15 h / 100 °C

2.1: 3.7 percent / DMAP; TEA / CH₂Cl₂ / 48 h / 20 °C

3.1: 85 percent / K₂CO₃; NaI / dimethylformamide / 48 h / 75 °C

With dmap; potassium hydroxide; TEA; potassium carbonate; sodium iodide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja001819f

Reference yield:

benzyl bromide (100-39-0) → 4-(4-formyl-phenoxy)-butyric acid 2-(2-benzyloxycarbonyl-3-{3-[4-(4-formyl-phenoxy)-butyryloxy]-2-[4-(4-formyl-phenoxy)-butyryloxymethyl]-2-methyl-propionyloxy}-2-methyl-propoxycarbonyl)-3-[4-(4-formyl-phenoxy)-butyryloxy]-2-methyl-propyl ester (364780-65-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: KOH / dimethylformamide / 1 h / 100 °C

1.2: 60 percent / dimethylformamide / 15 h / 100 °C

2.1: 3.7 percent / DMAP; TEA / CH₂Cl₂ / 48 h / 20 °C

3.1: 85 percent / K₂CO₃; NaI / dimethylformamide / 48 h / 75 °C

With dmap; potassium hydroxide; TEA; potassium carbonate; sodium iodide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja001819f

upstream raw materials:

4-hydroxy-benzaldehyde

4-bromo-butyric acid 2-{2-benzyloxycarbonyl-3-[3-(4-bromo-butyryloxy)-2-(4-bromo-butyryloxymethyl)-2-methyl-propionyloxy]-2-methyl-propoxycarbonyl}-3-(4-bromo-butyryloxy)-2-methyl-propyl ester

2,2-bis(hydroxymethyl)propionic acid

benzyl bromide

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