N-(1-((2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

Base Information

Chemical Name:N-(1-((2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide
CAS No.:1431531-58-6
Molecular Formula:C₂₂H₂₇ClN₂O₄
Molecular Weight:418.92
Hs Code.:

Synonyms:N-(1-((2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

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Chemical Property of N-(1-((2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

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Technology Process of N-(1-((2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

There total 11 articles about N-(1-((2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431533-82-2
6-(2-azidopropoxy)-2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole

: 108-24-7
acetic anhydride

: 1431531-58-6
N-(1-((2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

Guidance literature:: 6-(2-azidopropoxy)-2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole; With triphenylphosphine; In tetrahydrofuran;

acetic anhydride; With pyridine; at 20 ℃; for 0.166667h;

Reference yield:

: 1431533-77-5
3-chloro-4-(cyclopropylmethoxy)-N-(7-hydroxy-1,4-dioxaspiro[4.5]dec-8-yl)benzamide

: 1431531-58-6
N-(1-((2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 1 h / Inert atmosphere

1.2: 6 h / 60 °C

2.1: hydrogenchloride / methanol; tetrahydrofuran; water / 1 h / 70 °C

2.2: 0.33 h / 20 °C

3.1: potassium tert-butylate / tetrahydrofuran / 1 h / Inert atmosphere

4.1: tetrahydrofuran

4.2: 0.17 h / 20 °C

5.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran

5.2: 1 h / 100 °C

6.1: triphenylphosphine / tetrahydrofuran

6.2: 0.17 h / 20 °C

With hydrogenchloride; potassium tert-butylate; sulfur trioxide pyridine complex; methanesulfonyl chloride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; water; dimethyl sulfoxide;

Reference yield:

: 1431533-79-7
2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-ol

: 1431531-58-6
N-(1-((2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / Inert atmosphere

2.1: tetrahydrofuran

2.2: 0.17 h / 20 °C

3.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran

3.2: 1 h / 100 °C

4.1: triphenylphosphine / tetrahydrofuran

4.2: 0.17 h / 20 °C

With potassium tert-butylate; methanesulfonyl chloride; triethylamine; triphenylphosphine; In tetrahydrofuran;