6-(2-azidopropoxy)-2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole

Base Information

Chemical Name:6-(2-azidopropoxy)-2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole
CAS No.:1431533-82-2
Molecular Formula:C₂₀H₂₃ClN₄O₃
Molecular Weight:402.881
Hs Code.:

Synonyms:6-(2-azidopropoxy)-2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole

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Chemical Property of 6-(2-azidopropoxy)-2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole

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Technology Process of 6-(2-azidopropoxy)-2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole

There total 10 articles about 6-(2-azidopropoxy)-2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431533-81-1
1-((2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-yl)oxy)propan-2-ol

: 1431533-82-2
6-(2-azidopropoxy)-2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole

Guidance literature:: 1-((2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-yl)oxy)propan-2-ol; With methanesulfonyl chloride; triethylamine; In tetrahydrofuran;

With sodium azide; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

Reference yield:

: 1431533-80-0
2-((2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-6-yl)oxy)-1-(morpholin-4-yl)ethanone

: 1431533-82-2
6-(2-azidopropoxy)-2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran

1.2: 0.17 h / 20 °C

2.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran

2.2: 1 h / 100 °C

With methanesulfonyl chloride; triethylamine; In tetrahydrofuran;

Reference yield:

: 1431533-78-6
2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,7-dihydro-5H-spiro[1,3-benzoxazole-6,2'-[1,3]dioxolane]

: 1431533-82-2
6-(2-azidopropoxy)-2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / methanol; tetrahydrofuran; water / 1 h / 70 °C

1.2: 0.33 h / 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 1 h / Inert atmosphere

3.1: tetrahydrofuran

3.2: 0.17 h / 20 °C

4.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran

4.2: 1 h / 100 °C

With hydrogenchloride; potassium tert-butylate; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; water;