ethyl 3-[3-[[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]carbamoyl]phenyl]prop-2-enoate

Base Information

Chemical Name:ethyl 3-[3-[[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]carbamoyl]phenyl]prop-2-enoate
CAS No.:1383622-78-3
Molecular Formula:C₃₁H₂₄F₃N₅O₃
Molecular Weight:571.558
Hs Code.:

Synonyms:ethyl 3-[3-[[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]carbamoyl]phenyl]prop-2-enoate

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Chemical Property of ethyl 3-[3-[[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]carbamoyl]phenyl]prop-2-enoate

Chemical Property:

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Technology Process of ethyl 3-[3-[[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]carbamoyl]phenyl]prop-2-enoate

There total 7 articles about ethyl 3-[3-[[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]carbamoyl]phenyl]prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383622-77-2
3-bromo-N-[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]benzamide

: 140-88-5,9003-32-1
ethyl acrylate

: 1383622-78-3
ethyl 3-[3-[[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]carbamoyl]phenyl]prop-2-enoate

Guidance literature:: 3-bromo-N-[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]benzamide; ethyl acrylate; With N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; palladium diacetate; In N,N-dimethyl-formamide; at 110 ℃; for 18h; Inert atmosphere; Sealed;

With sodium hydrogencarbonate; In water; N,N-dimethyl-formamide;

Reference yield:

: 22019-50-7
2-bromo-1-(4-methyl-3-nitrophenyl)ethanone

: 1383622-78-3
ethyl 3-[3-[[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]carbamoyl]phenyl]prop-2-enoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetonitrile / 18 h / Reflux

1.2: 1 h / 20 °C

2.1: potassium acetate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / butan-1-ol; water / 4 h / 90 °C

3.1: acetic acid; iron / ethanol / 60 - 70 °C

4.1: pyridine / acetonitrile / 18 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine / palladium diacetate / N,N-dimethyl-formamide / 18 h / 110 °C / Inert atmosphere; Sealed

With pyridine; potassium acetate; iron; acetic acid; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; palladium diacetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;

Reference yield:

: 10397-30-5
4-methyl-3-nitrobenzoyl chloride

: 1383622-78-3
ethyl 3-[3-[[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]carbamoyl]phenyl]prop-2-enoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: dichloromethane; hexane / 2 h / 20 °C

1.2: 0 °C

2.1: acetonitrile / 18 h / Reflux

2.2: 1 h / 20 °C

3.1: potassium acetate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / butan-1-ol; water / 4 h / 90 °C

4.1: acetic acid; iron / ethanol / 60 - 70 °C

5.1: pyridine / acetonitrile / 18 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine / palladium diacetate / N,N-dimethyl-formamide / 18 h / 110 °C / Inert atmosphere; Sealed

With pyridine; potassium acetate; iron; acetic acid; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; palladium diacetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;