3-[3-[[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]carbamoyl]phenyl]prop-2-enoic acid

Base Information

Chemical Name:3-[3-[[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]carbamoyl]phenyl]prop-2-enoic acid
CAS No.:1383622-79-4
Molecular Formula:C₂₉H₂₀F₃N₅O₃
Molecular Weight:543.505
Hs Code.:

Synonyms:3-[3-[[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]carbamoyl]phenyl]prop-2-enoic acid

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Chemical Property of 3-[3-[[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]carbamoyl]phenyl]prop-2-enoic acid

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Technology Process of 3-[3-[[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]carbamoyl]phenyl]prop-2-enoic acid

There total 8 articles about 3-[3-[[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]carbamoyl]phenyl]prop-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383622-78-3
ethyl 3-[3-[[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]carbamoyl]phenyl]prop-2-enoate

: 1383622-79-4
3-[3-[[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]carbamoyl]phenyl]prop-2-enoic acid

Guidance literature:: ethyl 3-[3-[[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]carbamoyl]phenyl]prop-2-enoate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 50 ℃; for 1h;

With hydrogenchloride; In water; pH=2;

Reference yield:

: 22019-50-7
2-bromo-1-(4-methyl-3-nitrophenyl)ethanone

: 1383622-79-4
3-[3-[[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]carbamoyl]phenyl]prop-2-enoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetonitrile / 18 h / Reflux

1.2: 1 h / 20 °C

2.1: potassium acetate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / butan-1-ol; water / 4 h / 90 °C

3.1: acetic acid; iron / ethanol / 60 - 70 °C

4.1: pyridine / acetonitrile / 18 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine / palladium diacetate / N,N-dimethyl-formamide / 18 h / 110 °C / Inert atmosphere; Sealed

6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 50 °C

6.2: pH 2

With pyridine; water; potassium acetate; iron; acetic acid; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; sodium hydroxide; palladium diacetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;

Reference yield:

: 10397-30-5
4-methyl-3-nitrobenzoyl chloride

: 1383622-79-4
3-[3-[[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]carbamoyl]phenyl]prop-2-enoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloromethane; hexane / 2 h / 20 °C

1.2: 0 °C

2.1: acetonitrile / 18 h / Reflux

2.2: 1 h / 20 °C

3.1: potassium acetate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / butan-1-ol; water / 4 h / 90 °C

4.1: acetic acid; iron / ethanol / 60 - 70 °C

5.1: pyridine / acetonitrile / 18 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine / palladium diacetate / N,N-dimethyl-formamide / 18 h / 110 °C / Inert atmosphere; Sealed

7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 50 °C

7.2: pH 2

With pyridine; water; potassium acetate; iron; acetic acid; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; sodium hydroxide; palladium diacetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;