Methanesulfonic acid 1-(2-azido-ethyl)-6-[(3-azido-propyl)-(4-nitro-benzyloxycarbonyl)-amino]-hexyl ester

Base Information

Chemical Name:Methanesulfonic acid 1-(2-azido-ethyl)-6-[(3-azido-propyl)-(4-nitro-benzyloxycarbonyl)-amino]-hexyl ester
CAS No.:120476-80-4
Molecular Formula:C₂₀H₃₀N₈O₇S
Molecular Weight:526.574
Hs Code.:

Synonyms:Methanesulfonic acid 1-(2-azido-ethyl)-6-[(3-azido-propyl)-(4-nitro-benzyloxycarbonyl)-amino]-hexyl ester

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Chemical Property of Methanesulfonic acid 1-(2-azido-ethyl)-6-[(3-azido-propyl)-(4-nitro-benzyloxycarbonyl)-amino]-hexyl ester

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Technology Process of Methanesulfonic acid 1-(2-azido-ethyl)-6-[(3-azido-propyl)-(4-nitro-benzyloxycarbonyl)-amino]-hexyl ester

There total 7 articles about Methanesulfonic acid 1-(2-azido-ethyl)-6-[(3-azido-propyl)-(4-nitro-benzyloxycarbonyl)-amino]-hexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 124-63-0
methanesulfonyl chloride

: 120476-78-0
(8-Azido-6-hydroxy-octyl)-(3-azido-propyl)-carbamic acid 4-nitro-benzyl ester

: 120476-80-4
Methanesulfonic acid 1-(2-azido-ethyl)-6-[(3-azido-propyl)-(4-nitro-benzyloxycarbonyl)-amino]-hexyl ester

Guidance literature:: With triethylamine; In dichloromethane; Ambient temperature;
DOI:10.1021/jm00126a026

Reference yield:

: 1070-65-1
6-hydroxy-8-chlorooctanoic acid ethyl ester

: 120476-80-4
Methanesulfonic acid 1-(2-azido-ethyl)-6-[(3-azido-propyl)-(4-nitro-benzyloxycarbonyl)-amino]-hexyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: LiOH*H₂O / aq. ethanol / Ambient temperature

2: 89 percent / N-methylmorpholine, 1-N-hydroxybenzotriazole, dicyclohexylcarbodiimide / dimethylformamide / 96 h / Ambient temperature

3: 75.4 percent / B₂H₆ / tetrahydrofuran / Ambient temperature

4: 70 percent / 1M KOH / diethyl ether / Ambient temperature

5: 88 percent / LiN₃, LiI / dimethylformamide / 30 h / 60 °C

6: 99 percent / Et₃N / CH₂Cl₂ / Ambient temperature

With 4-methyl-morpholine; potassium hydroxide; lithium hydroxide; lithium azide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; lithium iodide; diborane; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00126a026

Reference yield:

: 90435-60-2
(+)-8-chloro-6-hydroxy-octanoic acid

: 120476-80-4
Methanesulfonic acid 1-(2-azido-ethyl)-6-[(3-azido-propyl)-(4-nitro-benzyloxycarbonyl)-amino]-hexyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / N-methylmorpholine, 1-N-hydroxybenzotriazole, dicyclohexylcarbodiimide / dimethylformamide / 96 h / Ambient temperature

2: 75.4 percent / B₂H₆ / tetrahydrofuran / Ambient temperature

3: 70 percent / 1M KOH / diethyl ether / Ambient temperature

4: 88 percent / LiN₃, LiI / dimethylformamide / 30 h / 60 °C

5: 99 percent / Et₃N / CH₂Cl₂ / Ambient temperature

With 4-methyl-morpholine; potassium hydroxide; lithium azide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; lithium iodide; diborane; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00126a026