2-(methylsulfonyl)ethyl 6-bromo-2,3-dihydro-α-<1-hydroxy-1-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2-butynyl>-2-oxo-1H-indole-3-acetate

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Chemical Name:2-(methylsulfonyl)ethyl 6-bromo-2,3-dihydro-α-<1-hydroxy-1-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2-butynyl>-2-oxo-1H-indole-3-acetate
CAS No.:158320-68-4
Molecular Formula:C₃₆H₃₄BrN₅O₁₀S
Molecular Weight:808.663
Hs Code.:
Mol file:158320-68-4.mol

2-(methylsulfonyl)ethyl 6-bromo-2,3-dihydro-α-<1-hydroxy-1-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2-butynyl>-2-oxo-1H-indole-3-acetate

Synonyms:2-(methylsulfonyl)ethyl 6-bromo-2,3-dihydro-α-<1-hydroxy-1-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2-butynyl>-2-oxo-1H-indole-3-acetate

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Chemical Property of 2-(methylsulfonyl)ethyl 6-bromo-2,3-dihydro-α-<1-hydroxy-1-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2-butynyl>-2-oxo-1H-indole-3-acetate Edit

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Technology Process of 2-(methylsulfonyl)ethyl 6-bromo-2,3-dihydro-α-<1-hydroxy-1-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2-butynyl>-2-oxo-1H-indole-3-acetate

There total 2 articles about 2-(methylsulfonyl)ethyl 6-bromo-2,3-dihydro-α-<1-hydroxy-1-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2-butynyl>-2-oxo-1H-indole-3-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 109681-02-9
3-[(2,6-Bis-benzyloxy-5-nitro-pyrimidin-4-ylamino)-methyl]-2-(6-bromo-2-oxo-2,3-dihydro-1H-indol-3-yl)-3-hydroxy-hex-4-ynoic acid 2-methylsulfanyl-ethyl ester

: 158320-68-4
2-(methylsulfonyl)ethyl 6-bromo-2,3-dihydro-α-<1-hydroxy-1-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2-butynyl>-2-oxo-1H-indole-3-acetate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 5 ℃; for 0.333333h;
DOI:10.1016/S0040-4020(01)86990-8

Reference yield:

: 94779-74-5
2-(methylthio)ethyl 6-bromo-2,3-dihydro-α-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>acetyl>-2-oxo-1H-indole-3-acetate

: 158320-68-4
2-(methylsulfonyl)ethyl 6-bromo-2,3-dihydro-α-<1-hydroxy-1-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>methyl>-2-butynyl>-2-oxo-1H-indole-3-acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent Turnov_. / tetrahydrofuran / 0.5 h / -60 °C

2: 91 percent / 80percent m-CPBA / CH₂Cl₂ / 0.33 h / 5 °C

With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(01)86990-8