2-(4-benzyloxy-butyl)-N,N'-bis-(2-hydroxy-1-phenyl-ethyl)-2-methyl-malonamide

Base Information

Chemical Name:2-(4-benzyloxy-butyl)-N,N'-bis-(2-hydroxy-1-phenyl-ethyl)-2-methyl-malonamide
CAS No.:807622-35-1
Molecular Formula:C₃₁H₃₈N₂O₅
Molecular Weight:518.653
Hs Code.:

2-(4-benzyloxy-butyl)-<i>N</i>,<i>N</i>'-bis-(2-hydroxy-1-phenyl-ethyl)-2-methyl-malonamide

Synonyms:2-(4-benzyloxy-butyl)-N,N'-bis-(2-hydroxy-1-phenyl-ethyl)-2-methyl-malonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-benzyloxy-butyl)-N,N'-bis-(2-hydroxy-1-phenyl-ethyl)-2-methyl-malonamide

Chemical Property:

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Technology Process of 2-(4-benzyloxy-butyl)-N,N'-bis-(2-hydroxy-1-phenyl-ethyl)-2-methyl-malonamide

There total 6 articles about 2-(4-benzyloxy-butyl)-N,N'-bis-(2-hydroxy-1-phenyl-ethyl)-2-methyl-malonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 20989-17-7
(2S)-2-phenylglycinol

: 364356-66-1
2-(4-benzyloxy-butyl)-2-methyl-propanedioyl dichloride

: 807622-35-1
2-(4-benzyloxy-butyl)-N,N'-bis-(2-hydroxy-1-phenyl-ethyl)-2-methyl-malonamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1016/j.tetasy.2004.08.015

Reference yield:

: 4541-14-4
4-benzyloxy-butan-1-ol

: 807622-35-1
2-(4-benzyloxy-butyl)-N,N'-bis-(2-hydroxy-1-phenyl-ethyl)-2-methyl-malonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / triethylamine; 4-dimethylaminopyridine / CH₂Cl₂ / 3 h / 0 °C

2: 70 percent / sodium hydride / tetrahydrofuran / 24 h / Heating

3: 80 percent / potassium hydroxide / 3 h / Heating

4: 100 percent / oxalyl chloride / CH₂Cl₂; dimethylformamide / 0 - 20 °C

5: 50 percent / triethylamine / CH₂Cl₂ / 1 h / 0 - 20 °C

With dmap; potassium hydroxide; oxalyl dichloride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2004.08.015

Reference yield:

: 100-39-0
benzyl bromide

: 807622-35-1
2-(4-benzyloxy-butyl)-N,N'-bis-(2-hydroxy-1-phenyl-ethyl)-2-methyl-malonamide

Guidance literature:: Multi-step reaction with 6 steps

1: 68 percent / sodium hydride / tetrahydrofuran / 18 h / Heating

2: 72 percent / triethylamine; 4-dimethylaminopyridine / CH₂Cl₂ / 3 h / 0 °C

3: 70 percent / sodium hydride / tetrahydrofuran / 24 h / Heating

4: 80 percent / potassium hydroxide / 3 h / Heating

5: 100 percent / oxalyl chloride / CH₂Cl₂; dimethylformamide / 0 - 20 °C

6: 50 percent / triethylamine / CH₂Cl₂ / 1 h / 0 - 20 °C

With dmap; potassium hydroxide; oxalyl dichloride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2004.08.015