1,1-dimethylethyl {1-(5-bromo-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl}methylcarbamate

Base Information

• Chemical Name: 1,1-dimethylethyl {1-(5-bromo-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl}methylcarbamate
• CAS No.: 1383342-95-7
• Molecular Formula: C₂₃H₂₈BrN₅O₄S
• Molecular Weight: 550.476
• Mol file: 1383342-95-7.mol

Synonyms:1,1-dimethylethyl {1-(5-bromo-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl}methylcarbamate

Chemical Property of 1,1-dimethylethyl {1-(5-bromo-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl}methylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-dimethylethyl {1-(5-bromo-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl}methylcarbamate

There total 2 articles about 1,1-dimethylethyl {1-(5-bromo-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl}methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-Benzenesulfonyl-5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine (252723-17-4) + tert-butyl methyl(piperidin-4-yl)carbamate (108612-54-0) → 1,1-dimethylethyl {1-(5-bromo-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl}methylcarbamate (1383342-95-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; at 150 ℃; for 0.333333h;

Reference yield:

5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine (22276-95-5) → 1,1-dimethylethyl {1-(5-bromo-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl}methylcarbamate (1383342-95-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

1.2: 1 h / Cooling

2.1: N-ethyl-N,N-diisopropylamine / 0.33 h / 150 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

Reference yield:

1,1-dimethylethyl {1-(5-bromo-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl}methylcarbamate (1383342-95-7) → 1-[5-bromo-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-N-methyl-4-piperidinamine (1383342-98-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 2h; Product distribution / selectivity;

upstream raw materials:

7-Benzenesulfonyl-5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

tert-butyl methyl(piperidin-4-yl)carbamate

5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

Downstream raw materials:

1-[5-bromo-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-N-methyl-4-piperidinamine

N-{1-[5-bromo-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4-piperidinyl}-N-methyl-4-pyridinecarboxamide