108612-54-0

Basic information

• Product Name: 4-N-Boc-4-N-Methyl-aminopiperidine
• Synonyms: tert-butyl n-methyl-n-(4-piperidyl)carbamate;4-AMINOPIPERIDINE-N-METHYL, N-BOC PROTECTED;4-N-BOC-4-N-METHYL-AMINOPIPERIDINE;METHYL-PIPERIDIN-4-YL-CARBAMIC ACID TERT-BUTYL ESTER;BUTTPARK 90\06-17;4-(Methylamino)piperidine, N4-BOC protected;4-Boc-4-methylaminopiperidine;4-Boc-methylaminopiperidine
• CAS NO: 108612-54-0
• Molecular Formula: C₁₁H₂₂N₂O₂
• Molecular Weight: 214.3
• EINECS: 1312995-182-4
• Product Categories: Piperidine
• Mol File: 108612-54-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 50°C(lit.)
• Boiling Point: 287.9 °C at 760 mmHg
• Flash Point: 127.9 °C
• Appearance: /
• Density: 1.01 g/cm³
• Vapor Pressure: 0.00242mmHg at 25°C
• Refractive Index: 1.485
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.05±0.10(Predicted)
• CAS DataBase Reference: 4-N-Boc-4-N-Methyl-aminopiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-N-Boc-4-N-Methyl-aminopiperidine(108612-54-0)
• EPA Substance Registry System: 4-N-Boc-4-N-Methyl-aminopiperidine(108612-54-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-28-36-44
• Hazardous Substances Data: 108612-54-0(Hazardous Substances Data)

Usage

General Description

4-N-Boc-4-N-Methyl-aminopiperidine is a chemical compound often used in pharmaceutical research. It is a member of the piperidines class of compounds, which are widely prevalent in many pharmaceutical drugs and natural products. This specific compound, with the inclusion of the Boc protection group, is often used as a reagent in the synthesis of various pharmaceuticals. The Boc (tert-butyloxycarbonyl) group in this chemical aids in the protection of amines during chemical synthesis thereby enhancing the overall process. Its properties can change depending on its specific derivative, but, in general, it is typically a stable compound under normal conditions.

InChI:InChI=1/C11H22N2O2/c1-11(2,3)15-10(14)13(4)9-5-7-12-8-6-9/h9,12H,5-8H2,1-4H3

Upstream product

• 139062-92-3 N-tert-Butoxycarbonyl-N-methyl-1-benzyl-4-piperidinamine 
• 50541-93-0 4-amino-1-benzylpiperidine 
• 7006-50-0 1-benzyl-N-methylpiperidin-4-amine 
• 73889-19-7 tert-butyl (1-benzylpiperidin-4-yl)carbamate 
• 405057-76-3 4-(tert-butoxycarbonyl-methyl-amino)-piperidine-1-carboxylic acid benzyl ester 
• 3612-20-2 1-phenylmethyl-4-piperidone 

Downstream Products

• 1123241-94-0 tert-butyl (1-(2-chloropyrimidin-4-yl)piperidin-4-yl)methylcarbamate 
• 911693-60-2 1,1-dimethylethyl {1-[8-(2,6-difluorophenyl)-4-(5-{[(4-fluorophenyl)amino]carbonyl}-2-methylphenyl)-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-2-yl]-4-piperidinyl}methylcarbamate 
• 917610-02-7 tert-butyl {1-[1-(diphenylmethyl)azetidin-3-yl]piperidin-4-yl}methylcarbamate 
• 1365156-90-6 tert-butyl methyl(1-(6-methylpyrazin-2-yl)piperidin-4-yl)carbamate 
• 405058-03-9 1-(3'-pyridyl)-4-(N-Boc-N-methyl)aminopiperidine 
• 1073523-37-1 methyl-[1-(3-trifluoromethyl-benzyl)-piperidin-4-yl]-amine 
• 1073523-24-6 6-{methyl-[1-(3-trifluoromethyl-benzyl)-piperidin-4-yl]-amino}-nicotinonitrile 

Relevant articles and documents

An efficient palladium-catalyzed synthesis of 1-heteroaryl-4-aminopiperidine derivatives from heteroaryl chlorides

An efficient protocol for the synthesis of 1-heteroaryl-4-(N-methyl)aminopiperidines starting from heteroaryl chloride derivatives is described. A broad range of 1-heteroaryl-4-(N-Boc-N-methyl)aminopiperidine derivatives were obtained in good to excellent

BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS

The invention provides novel bis-pyridylpyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy and for the treatment of obesity and/or diabetes.

N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists

Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.