2-(2-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)benzyl)thiazol-5-yl)-1,3,4-thiadiazole

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Chemical Name:2-(2-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)benzyl)thiazol-5-yl)-1,3,4-thiadiazole
CAS No.:1260242-53-2
Molecular Formula:C₄₆H₄₂ClN₃O₅S₂
Molecular Weight:816.442
Hs Code.:

Synonyms:2-(2-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)benzyl)thiazol-5-yl)-1,3,4-thiadiazole

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Chemical Property of 2-(2-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)benzyl)thiazol-5-yl)-1,3,4-thiadiazole

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Technology Process of 2-(2-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)benzyl)thiazol-5-yl)-1,3,4-thiadiazole

There total 10 articles about 2-(2-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)benzyl)thiazol-5-yl)-1,3,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1352714-17-0
C₄₆H₄₄ClN₃O₇S

: 1260242-53-2
2-(2-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)benzyl)thiazol-5-yl)-1,3,4-thiadiazole

Guidance literature:: With Lawessons reagent; In tetrahydrofuran; for 3h; Reflux; Inert atmosphere;

Reference yield:

: 1225430-37-4
(2-chloro-5-((3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)methanol

: 1260242-53-2
2-(2-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)benzyl)thiazol-5-yl)-1,3,4-thiadiazole

Guidance literature:: Multi-step reaction with 10 steps

1.1: pyridine; phosphorus tribromide / diethyl ether / 16 h / 0 °C / Reflux; Inert atmosphere

2.1: ethanol; water / 15 h / Reflux

3.1: sodium hydroxide; water / ethanol / Reflux

3.2: 20 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 5.25 h / 0 - 20 °C / Inert atmosphere

5.1: ammonium hydroxide / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere

6.1: Lawessons reagent / tetrahydrofuran / 15 h / Reflux; Inert atmosphere

7.1: pyridine / ethanol / 15 h / 80 °C / Inert atmosphere

8.1: potassium hydroxide; ethanol / tetrahydrofuran / 2 h / Reflux; Inert atmosphere

9.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

10.1: Lawessons reagent / tetrahydrofuran / 3 h / Reflux; Inert atmosphere

With Lawessons reagent; 4-methyl-morpholine; pyridine; ammonium hydroxide; oxalyl dichloride; ethanol; water; phosphorus tribromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1260242-00-9
(2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-2-(benzyloxymethyl)-6-(3-(bromomethyl)-4-chlorophenyl)-tetrahydro-2H-pyran

: 1260242-53-2
2-(2-(2-chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)benzyl)thiazol-5-yl)-1,3,4-thiadiazole

Guidance literature:: Multi-step reaction with 9 steps

1.1: ethanol; water / 15 h / Reflux

2.1: sodium hydroxide; water / ethanol / Reflux

2.2: 20 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 5.25 h / 0 - 20 °C / Inert atmosphere

4.1: ammonium hydroxide / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere

5.1: Lawessons reagent / tetrahydrofuran / 15 h / Reflux; Inert atmosphere

6.1: pyridine / ethanol / 15 h / 80 °C / Inert atmosphere

7.1: potassium hydroxide; ethanol / tetrahydrofuran / 2 h / Reflux; Inert atmosphere

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

9.1: Lawessons reagent / tetrahydrofuran / 3 h / Reflux; Inert atmosphere

With Lawessons reagent; 4-methyl-morpholine; pyridine; ammonium hydroxide; oxalyl dichloride; ethanol; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;