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1225430-37-4

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1225430-37-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1225430-37-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,5,4,3 and 0 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1225430-37:
(9*1)+(8*2)+(7*2)+(6*5)+(5*4)+(4*3)+(3*0)+(2*3)+(1*7)=114
114 % 10 = 4
So 1225430-37-4 is a valid CAS Registry Number.

1225430-37-4Downstream Products

1225430-37-4Relevant articles and documents

Novel C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents: Pyridazinylmethylphenyl glucoside congeners

Kim, Min Ju,Lee, Junwon,Kang, Suk Youn,Lee, Sung-Han,Son, Eun-Jung,Jung, Myung Eun,Lee, Suk Ho,Song, Kwang-Seop,Lee, MinWoo,Han, Ho-Kyun,Kim, Jeongmin,Lee, Jinhwa

supporting information; scheme or table, p. 3420 - 3425 (2010/08/07)

Novel C-aryl glucoside SGLT2 inhibitors containing pyridazine motif were designed and synthesized for biological evaluation. Among the compounds tested, pyridazine containing methylthio moiety 22l or thiadiazole ring 22ah showed the best in vitro inhibitory activities in this series (IC50 = 13.4, 11.4 nM, respectively) against SGLT2 to date. Subsequently, compound 22l exhibited reasonable urinary glucose excretion and glucosuria in normal SD rats, thereby demonstrating that this pyridazine series possesses both in vitro SGLT2 inhibition and in vivo efficacy, albeit to a lower degree.

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