(3S,4S)-methyl 4-(3-(benzyloxy)-4-methoxyphenyl)-3-methyl-2-oxopyrrolidine-3-carboxylate

Base Information

Chemical Name:(3S,4S)-methyl 4-(3-(benzyloxy)-4-methoxyphenyl)-3-methyl-2-oxopyrrolidine-3-carboxylate
CAS No.:791807-34-6
Molecular Formula:C₂₁H₂₃NO₅
Molecular Weight:369.417
Hs Code.:

Synonyms:(3S,4S)-methyl 4-(3-(benzyloxy)-4-methoxyphenyl)-3-methyl-2-oxopyrrolidine-3-carboxylate

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Chemical Property of (3S,4S)-methyl 4-(3-(benzyloxy)-4-methoxyphenyl)-3-methyl-2-oxopyrrolidine-3-carboxylate

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Technology Process of (3S,4S)-methyl 4-(3-(benzyloxy)-4-methoxyphenyl)-3-methyl-2-oxopyrrolidine-3-carboxylate

There total 4 articles about (3S,4S)-methyl 4-(3-(benzyloxy)-4-methoxyphenyl)-3-methyl-2-oxopyrrolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 2-[(S)-2-Amino-1-(3-benzyloxy-4-methoxy-phenyl)-ethyl]-2-methyl-malonic acid dimethyl ester

: 791807-34-6
(3S,4S)-methyl 4-(3-(benzyloxy)-4-methoxyphenyl)-3-methyl-2-oxopyrrolidine-3-carboxylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at -78 ℃; for 1h;

Reference yield:

: 609-02-9
methyl-malonic acid dimethylester

: 791807-34-6
(3S,4S)-methyl 4-(3-(benzyloxy)-4-methoxyphenyl)-3-methyl-2-oxopyrrolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: chiral bis(oxazoline)-based ligand; Mg(OTf)2; N-methylmorpholine / 4 Angstroem molecular sieves / CHCl₃; H₂O / 18 h / 20 °C

2: Zn dust; aq. HCl / ethanol / 45 - 52 °C

3: aq. NaHCO₃ / CH₂Cl₂

With 4-methyl-morpholine; hydrogenchloride; chiral bis(oxazoline)-based ligand; sodium hydrogencarbonate; magnesium triflate; zinc; 4 A molecular sieve; In ethanol; dichloromethane; chloroform; water;
DOI:10.1021/ol060398p

Reference yield:

: 63909-29-5
(E)-2-(benzyloxy)-1-methoxy-4-(2-nitrovinyl)benzene

: 791807-34-6
(3S,4S)-methyl 4-(3-(benzyloxy)-4-methoxyphenyl)-3-methyl-2-oxopyrrolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: chiral bis(oxazoline)-based ligand; Mg(OTf)2; N-methylmorpholine / 4 Angstroem molecular sieves / CHCl₃; H₂O / 18 h / 20 °C

2: Zn dust; aq. HCl / ethanol / 45 - 52 °C

3: aq. NaHCO₃ / CH₂Cl₂

With 4-methyl-morpholine; hydrogenchloride; chiral bis(oxazoline)-based ligand; sodium hydrogencarbonate; magnesium triflate; zinc; 4 A molecular sieve; In ethanol; dichloromethane; chloroform; water;
DOI:10.1021/ol060398p