1-((3S,4S)-4-(3-(benzyloxy)-4-methoxyphenyl)-3-methyl-pyrrolidin-3-yl)ethanone

Base Information

Chemical Name:1-((3S,4S)-4-(3-(benzyloxy)-4-methoxyphenyl)-3-methyl-pyrrolidin-3-yl)ethanone
CAS No.:884846-87-1
Molecular Formula:C₂₁H₂₃NO₄
Molecular Weight:353.418
Hs Code.:

Synonyms:1-((3S,4S)-4-(3-(benzyloxy)-4-methoxyphenyl)-3-methyl-pyrrolidin-3-yl)ethanone

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Chemical Property of 1-((3S,4S)-4-(3-(benzyloxy)-4-methoxyphenyl)-3-methyl-pyrrolidin-3-yl)ethanone

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Technology Process of 1-((3S,4S)-4-(3-(benzyloxy)-4-methoxyphenyl)-3-methyl-pyrrolidin-3-yl)ethanone

There total 5 articles about 1-((3S,4S)-4-(3-(benzyloxy)-4-methoxyphenyl)-3-methyl-pyrrolidin-3-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-[(3R,4S)-4-(3-Benzyloxy-4-methoxy-phenyl)-3-methyl-2-oxo-pyrrolidin-3-yl]-3-oxo-propionic acid tert-butyl ester

: 884846-87-1
1-((3S,4S)-4-(3-(benzyloxy)-4-methoxyphenyl)-3-methyl-pyrrolidin-3-yl)ethanone

Guidance literature:: With toluene-4-sulfonic acid; In toluene; at 90 ℃;
DOI:10.1021/ol060398p

Reference yield:

: 63909-29-5
(E)-2-(benzyloxy)-1-methoxy-4-(2-nitrovinyl)benzene

: 884846-87-1
1-((3S,4S)-4-(3-(benzyloxy)-4-methoxyphenyl)-3-methyl-pyrrolidin-3-yl)ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: chiral bis(oxazoline)-based ligand; Mg(OTf)2; N-methylmorpholine / 4 Angstroem molecular sieves / CHCl₃; H₂O / 18 h / 20 °C

2: Zn dust; aq. HCl / ethanol / 45 - 52 °C

3: aq. NaHCO₃ / CH₂Cl₂

4: LiHMDS / toluene; tetrahydrofuran / 10 - 15 °C

5: pTSA / toluene / 90 °C

With 4-methyl-morpholine; hydrogenchloride; chiral bis(oxazoline)-based ligand; sodium hydrogencarbonate; toluene-4-sulfonic acid; magnesium triflate; lithium hexamethyldisilazane; zinc; 4 A molecular sieve; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; toluene;
DOI:10.1021/ol060398p

Reference yield:

: 791807-34-6
(3S,4S)-methyl 4-(3-(benzyloxy)-4-methoxyphenyl)-3-methyl-2-oxopyrrolidine-3-carboxylate

: 884846-87-1
1-((3S,4S)-4-(3-(benzyloxy)-4-methoxyphenyl)-3-methyl-pyrrolidin-3-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: LiHMDS / toluene; tetrahydrofuran / 10 - 15 °C

2: pTSA / toluene / 90 °C

With toluene-4-sulfonic acid; lithium hexamethyldisilazane; In tetrahydrofuran; toluene;
DOI:10.1021/ol060398p