5-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-3-(3,4,5-trimethoxyphenyl)isoxazole

Base Information

Chemical Name:5-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-3-(3,4,5-trimethoxyphenyl)isoxazole
CAS No.:831222-67-4
Molecular Formula:C₂₅H₃₃NO₆Si
Molecular Weight:471.626
Hs Code.:

Synonyms:5-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-3-(3,4,5-trimethoxyphenyl)isoxazole

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Chemical Property of 5-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-3-(3,4,5-trimethoxyphenyl)isoxazole

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Technology Process of 5-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-3-(3,4,5-trimethoxyphenyl)isoxazole

There total 8 articles about 5-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-3-(3,4,5-trimethoxyphenyl)isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 831222-66-3
5-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-3-(3,4,5-trimethoxyphenyl)-4,5-dihydroisoxazole

: 831222-67-4
5-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-3-(3,4,5-trimethoxyphenyl)isoxazole

Guidance literature:: With manganese(IV) oxide; In benzene; Heating;
DOI:10.1021/jm049622b

Reference yield: 53.0%

: 863479-34-9
3-(tert-butyldimethylsiloxy)-4-methoxyphenylacetylene

: 39201-89-3
3,4,5-trimethoxybenzaldehyde oxime

: 831222-67-4
5-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-3-(3,4,5-trimethoxyphenyl)isoxazole

Guidance literature:: With sodium hypochlorite; triethylamine; In dichloromethane; water; at 0 - 20 ℃; for 25h;
DOI:10.1016/j.bmc.2006.02.001

Reference yield:

: 97315-18-9
p-methoxy-m-(tert-butyldimethylsilyloxy)-benzaldehyde

: 831222-67-4
5-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-3-(3,4,5-trimethoxyphenyl)isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 67 percent / NaH / tetrahydrofuran / 5 h / 20 °C

2.1: N-chlorosuccinimide; pyridine / CHCl₃ / 1 h / 50 - 60 °C

2.2: 67 percent / triethylamine / CHCl₃ / 0.33 h / 25 °C

3.1: 99 percent / MnO₂ / benzene / Heating

With pyridine; manganese(IV) oxide; N-chloro-succinimide; sodium hydride; In tetrahydrofuran; chloroform; benzene; 1.1: Wittig reaction;
DOI:10.1021/jm049622b