(R)-2-[Benzyloxy-((S)-1-tert-butoxycarbonylamino-ethyl)-phosphinoyloxy]-propionic acid benzyl ester

Base Information

Chemical Name:(R)-2-[Benzyloxy-((S)-1-tert-butoxycarbonylamino-ethyl)-phosphinoyloxy]-propionic acid benzyl ester
CAS No.:444188-72-1
Molecular Formula:C₂₄H₃₂NO₇P
Molecular Weight:477.494
Hs Code.:

Synonyms:(R)-2-[Benzyloxy-((S)-1-tert-butoxycarbonylamino-ethyl)-phosphinoyloxy]-propionic acid benzyl ester

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Chemical Property of (R)-2-[Benzyloxy-((S)-1-tert-butoxycarbonylamino-ethyl)-phosphinoyloxy]-propionic acid benzyl ester

Chemical Property:

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Technology Process of (R)-2-[Benzyloxy-((S)-1-tert-butoxycarbonylamino-ethyl)-phosphinoyloxy]-propionic acid benzyl ester

There total 1 articles about (R)-2-[Benzyloxy-((S)-1-tert-butoxycarbonylamino-ethyl)-phosphinoyloxy]-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2051-96-9,56777-24-3,74094-05-6
benzyl (R)-Lactate

: (1-tert-butoxycarbonylamino-ethyl)-phosphonic acid monobenzyl ester; compound with adamantan-1-ylamine

: 444188-72-1
(R)-2-[Benzyloxy-((S)-1-tert-butoxycarbonylamino-ethyl)-phosphinoyloxy]-propionic acid benzyl ester

Guidance literature:: (1-tert-butoxycarbonylamino-ethyl)-phosphonic acid monobenzyl ester; compound with adamantan-1-ylamine; With hydrogenchloride;

benzyl (R)-Lactate; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
DOI:10.1016/S0960-894X(02)00047-1

Reference yield:

: 444188-72-1
(R)-2-[Benzyloxy-((S)-1-tert-butoxycarbonylamino-ethyl)-phosphinoyloxy]-propionic acid benzyl ester

: (R)-2-[((S)-1-Amino-ethyl)-benzyloxy-phosphinoyloxy]-propionic acid benzyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(02)00047-1

Reference yield:

: 444188-72-1
(R)-2-[Benzyloxy-((S)-1-tert-butoxycarbonylamino-ethyl)-phosphinoyloxy]-propionic acid benzyl ester

: 444188-73-2
(R)-2-{[(S)-1-((S)-6-Acetylamino-2-tert-butoxycarbonylamino-hexanoylamino)-ethyl]-benzyloxy-phosphinoyloxy}-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / CH₂Cl₂

2: HBTU; NMM

With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(02)00047-1