(R)-2-({(S)-1-[(S)-6-Acetylamino-2-(3-tert-butoxycarbonylamino-propionylamino)-hexanoylamino]-ethyl}-benzyloxy-phosphinoyloxy)-propionic acid benzyl ester

Base Information

Chemical Name:(R)-2-({(S)-1-[(S)-6-Acetylamino-2-(3-tert-butoxycarbonylamino-propionylamino)-hexanoylamino]-ethyl}-benzyloxy-phosphinoyloxy)-propionic acid benzyl ester
CAS No.:444188-74-3
Molecular Formula:C₃₅H₅₁N₄O₁₀P
Molecular Weight:718.784
Hs Code.:

(R)-2-({(S)-1-[(S)-6-Acetylamino-2-(3-tert-butoxycarbonylamino-propionylamino)-hexanoylamino]-ethyl}-benzyloxy-phosphinoyloxy)-propionic acid benzyl ester

Synonyms:(R)-2-({(S)-1-[(S)-6-Acetylamino-2-(3-tert-butoxycarbonylamino-propionylamino)-hexanoylamino]-ethyl}-benzyloxy-phosphinoyloxy)-propionic acid benzyl ester

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Chemical Property of (R)-2-({(S)-1-[(S)-6-Acetylamino-2-(3-tert-butoxycarbonylamino-propionylamino)-hexanoylamino]-ethyl}-benzyloxy-phosphinoyloxy)-propionic acid benzyl ester

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Technology Process of (R)-2-({(S)-1-[(S)-6-Acetylamino-2-(3-tert-butoxycarbonylamino-propionylamino)-hexanoylamino]-ethyl}-benzyloxy-phosphinoyloxy)-propionic acid benzyl ester

There total 7 articles about (R)-2-({(S)-1-[(S)-6-Acetylamino-2-(3-tert-butoxycarbonylamino-propionylamino)-hexanoylamino]-ethyl}-benzyloxy-phosphinoyloxy)-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2051-96-9,56777-24-3,74094-05-6
benzyl (R)-Lactate

: 444188-74-3
(R)-2-({(S)-1-[(S)-6-Acetylamino-2-(3-tert-butoxycarbonylamino-propionylamino)-hexanoylamino]-ethyl}-benzyloxy-phosphinoyloxy)-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: aq. HCl

1.2: BOP; DIPEA

2.1: TFA / CH₂Cl₂

3.1: HBTU; NMM

4.1: TFA / CH₂Cl₂

5.1: HBTU; NMM

With 4-methyl-morpholine; hydrogenchloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(02)00047-1

Reference yield:

: 6404-26-8
(S)-6-acetamido-2-((tertbutoxycarbonyl)amino)hexanoic acid

: 444188-74-3
(R)-2-({(S)-1-[(S)-6-Acetylamino-2-(3-tert-butoxycarbonylamino-propionylamino)-hexanoylamino]-ethyl}-benzyloxy-phosphinoyloxy)-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: HBTU; NMM

2: TFA / CH₂Cl₂

3: HBTU; NMM

With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(02)00047-1

Reference yield:

: (R)-2-[((S)-1-Amino-ethyl)-benzyloxy-phosphinoyloxy]-propionic acid benzyl ester

: 444188-74-3
(R)-2-({(S)-1-[(S)-6-Acetylamino-2-(3-tert-butoxycarbonylamino-propionylamino)-hexanoylamino]-ethyl}-benzyloxy-phosphinoyloxy)-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: HBTU; NMM

2: TFA / CH₂Cl₂

3: HBTU; NMM

With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(02)00047-1