2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-N-(4-methyl-1,3-thiazol-2-yl)hexanamide

Base Information

Chemical Name:2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-N-(4-methyl-1,3-thiazol-2-yl)hexanamide
CAS No.:1207760-80-2
Molecular Formula:C₂₁H₂₁ClN₆O₂S
Molecular Weight:456.956
Hs Code.:

Synonyms:2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-N-(4-methyl-1,3-thiazol-2-yl)hexanamide

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Chemical Property of 2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-N-(4-methyl-1,3-thiazol-2-yl)hexanamide

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Technology Process of 2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-N-(4-methyl-1,3-thiazol-2-yl)hexanamide

There total 4 articles about 2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-N-(4-methyl-1,3-thiazol-2-yl)hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852313-98-5
4-chloro-1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine

: 1207831-17-1
2-hydroxy-N-(4-methyl-1,3-thiazol-2-yl)hexanamide

: 1207760-80-2
2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-N-(4-methyl-1,3-thiazol-2-yl)hexanamide

Guidance literature:: 2-hydroxy-N-(4-methyl-1,3-thiazol-2-yl)hexanamide; With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃;

4-chloro-1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine; In tetrahydrofuran; at 50 ℃;
DOI:10.1016/j.bmcl.2012.10.090

Reference yield:

: 1006597-09-6
1-(2-chloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

: 1207760-80-2
2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-N-(4-methyl-1,3-thiazol-2-yl)hexanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 12 h / Reflux

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 20 °C

2.2: 50 °C

With lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2012.10.090

Reference yield:

: 64096-89-5
5-amino-1-(2-chlorophenyl)-1H-pyrazole-4-carbonitrile

: 1207760-80-2
2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-N-(4-methyl-1,3-thiazol-2-yl)hexanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 0.5 h / 20 °C

2.1: 0.5 h / 210 °C / Microwave irradiation

3.1: trichlorophosphate / 12 h / Reflux

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 20 °C

4.2: 50 °C

With sulfuric acid; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2012.10.090