5-AMINO-1-(2-CHLOROPHENYL)-1H-PYRAZOLE-4

Base Information

• Chemical Name: 5-AMINO-1-(2-CHLOROPHENYL)-1H-PYRAZOLE-4
• CAS No.: 64096-89-5
• Molecular Formula: C10H7ClN4
• Molecular Weight: 218.645
• Hs Code.: 2933199090
• Mol file: 64096-89-5.mol

Synonyms:Pyrazole-4-carbonitrile,5-amino-1-(o-chlorophenyl)- (6CI);5-Amino-1-(2-chlorophenyl)-1H-pyrazole-4-carbonitrile;

Chemical Property of 5-AMINO-1-(2-CHLOROPHENYL)-1H-PYRAZOLE-4

Chemical Property:

• Melting Point: 136-140 °C
• Boiling Point: 433.947 °C at 760 mmHg
• Flash Point: 216.244 °C
• PSA: 67.63000
• LogP: 2.56078

Purity/Quality:

99% ^*data from raw suppliers

5-Amino-1-(2-chlorophenyl)-1H-pyrazole-4-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 5-AMINO-1-(2-CHLOROPHENYL)-1H-PYRAZOLE-4

There total 6 articles about 5-AMINO-1-(2-CHLOROPHENYL)-1H-PYRAZOLE-4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

o-chlorophenylhydrazine hydrochloride (41052-75-9) + Ethoxymethylenemalononitrile (123-06-8) → 5-amino-1-(2-chlorophenyl)-1H-pyrazole-4-carbonitrile (64096-89-5)

Guidance literature:

With triethylamine; In ethanol; at 20 ℃; for 1.5h; Reflux; Inert atmosphere;

DOI:10.1021/jm100095x

Reference yield: 80.0%

Ethoxymethylenemalononitrile (123-06-8) + (2-chlorophenyl)hydrazine (10449-07-7) → 5-amino-1-(2-chlorophenyl)-1H-pyrazole-4-carbonitrile (64096-89-5)

Guidance literature:

In ethanol; for 1h; Reflux;

DOI:10.1016/j.bmcl.2012.10.090

Reference yield: 78.0%

→ 5-amino-1-(2-chlorophenyl)-1H-pyrazole-4-carbonitrile (64096-89-5)

Guidance literature:

upstream raw materials:

Ethoxymethylenemalononitrile

(2-chlorophenyl)hydrazine

orthoformic acid triethyl ester

malononitrile

Downstream raw materials:

4-Amino-1-(2-chloro-phenyl)-5-methyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-6-one

4H-Pyrazolo<1,5-a>benzimidazole-3-carbonitrile

5-amino-1-(2-chloro-phenyl)-1H-pyrazole-4-carboxylic acid amide

6-methyl-1-(2-chlorophenyl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one

Refernces

• 1、 Bonn, Peter,Brink, D. Mikael,F?gerhag, Jonas,Jurva, Ulrik,Robb, Graeme R.,Schnecke, Volker,Svensson Henriksson, Anette,Waring, Michael J.,Westerlund, Christer. "The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold". . p. 7302 - 7305. Retrieved 2013/02/23.
• 2、 Dos Santos, Mauricio S.,Bernardino, Alice M. R.,Pinheiro, Luiz C. S.,Canto-Cavalheiro, Marilene M.,Leon, Leonor L.. "An efficient synthesis of new 5-(1-Aryl-1H-pyrazole-4-yl)-1H-tetrazoles from 1-Aryl-1H-pyrazole-4-carbonitriles via [3 + 2] cycloaddition reaction". . p. 1425 - 1428. Retrieved 2013/02/23.