134848-96-7Relevant articles and documents
Photoswitchable NHC-promoted ring-opening polymerizations
Neilson, Bethany M.,Bielawski, Christopher W.
, p. 5453 - 5455 (2013)
The UV-induced photocyclization of a dithienylethene-annulated N-heterocyclic carbene precatalyst enabled photoswitchable ring-opening polymerizations of ε-caprolactone and δ-valerolactone. The polymerizations proceeded efficiently in ambient light, however UV irradiation attenuated the reaction rate (kamb/kUV = 59). Subsequent visible light exposure reversed the photocyclization and restored catalytic activity.
TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE
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Paragraph 0992, (2021/02/12)
The present disclosure relates to bifunctional compounds, which find utility as modulators of tan protein. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a VHL or cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds tan protein, such that tan protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of tan. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of tan protein. Diseases or disorders that result from aggregation or accumulation of tan protein are treated or prevented with compounds and compositions of the present disclosure.
Modified oligonucleotides and compound that can be used for synthesizing same
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, (2020/12/08)
The present disclosure falls within the field of biomedical technology, and in particular relates to modified oligonucleatides and a compound that can be used for synthesizing same and a method for modifying oligonucleotides. The present disclosure also relates to the use of the modified oligonucleotides for preventing and/or treating diseases associated with the liver in a subject.