N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaboran-2-yl)phenyl)-1-(trifluoromethyl)cyclopropanecarboxamide

Base Information

• Chemical Name: N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaboran-2-yl)phenyl)-1-(trifluoromethyl)cyclopropanecarboxamide
• CAS No.: 1318780-16-3
• Molecular Formula: C₁₇H₂₁BF₃NO₃
• Molecular Weight: 355.165
• Mol file: 1318780-16-3.mol

Synonyms:N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaboran-2-yl)phenyl)-1-(trifluoromethyl)cyclopropanecarboxamide

Chemical Property of N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaboran-2-yl)phenyl)-1-(trifluoromethyl)cyclopropanecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaboran-2-yl)phenyl)-1-(trifluoromethyl)cyclopropanecarboxamide

There total 1 articles about N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaboran-2-yl)phenyl)-1-(trifluoromethyl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

1-(trifluoromethyl)cyclopropanecarboxylic acid (277756-46-4) + 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline (214360-73-3) → N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaboran-2-yl)phenyl)-1-(trifluoromethyl)cyclopropanecarboxamide (1318780-16-3)

Guidance literature:

1-(trifluoromethyl)cyclopropanecarboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 1h;

4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1021/ml200163b

Reference yield: 93.0%

N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaboran-2-yl)phenyl)-1-(trifluoromethyl)cyclopropanecarboxamide (1318780-16-3) + N-tert-butyl-3-((6-chloro-4-(2,2,2-trifluoroethylamino)pyrido[3,2,d]pyrimidin-2-ylamino)methyl)-5-(trifluoromethyl)benzenesulfonamide (1318780-12-9) → C32H30F9N7O3S (1352577-51-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 130 ℃; for 0.5h; Microwave irradiation;

DOI:10.1021/ml200163b

Reference yield:

N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaboran-2-yl)phenyl)-1-(trifluoromethyl)cyclopropanecarboxamide (1318780-16-3) + N-tert-butyl-3-((6-chloro-4-(2,2,2-trifluoroethylamino)pyrido[3,2,d]pyrimidin-2-ylamino)methyl)-5-(trifluoromethyl)benzenesulfonamide (1318780-12-9) → C28H22F9N7O3S (1318780-07-2)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 130 °C / Microwave irradiation

2: trifluoroacetic acid / 6 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; trifluoroacetic acid; In 1,2-dimethoxyethane; water;

DOI:10.1021/ml200163b

upstream raw materials:

1-(trifluoromethyl)cyclopropanecarboxylic acid

4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline

Downstream raw materials:

C₂₈H₂₂F₉N₇O₃S

C₃₂H₃₀F₉N₇O₃S