(3S,4S)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-3-(4-fluoro-2-methylphenyl)-1-[(1-glycoloylpiperidin-4-yl)carbonyl]-N-methylpiperidine-4-carboxamide

Base Information

Chemical Name:(3S,4S)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-3-(4-fluoro-2-methylphenyl)-1-[(1-glycoloylpiperidin-4-yl)carbonyl]-N-methylpiperidine-4-carboxamide
CAS No.:1076227-97-8
Molecular Formula:C₃₂H₃₆F₇N₃O₄
Molecular Weight:659.644
Hs Code.:

(3S,4S)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-3-(4-fluoro-2-methylphenyl)-1-[(1-glycoloylpiperidin-4-yl)carbonyl]-N-methylpiperidine-4-carboxamide

Synonyms:(3S,4S)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-3-(4-fluoro-2-methylphenyl)-1-[(1-glycoloylpiperidin-4-yl)carbonyl]-N-methylpiperidine-4-carboxamide

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Chemical Property of (3S,4S)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-3-(4-fluoro-2-methylphenyl)-1-[(1-glycoloylpiperidin-4-yl)carbonyl]-N-methylpiperidine-4-carboxamide

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Technology Process of (3S,4S)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-3-(4-fluoro-2-methylphenyl)-1-[(1-glycoloylpiperidin-4-yl)carbonyl]-N-methylpiperidine-4-carboxamide

There total 6 articles about (3S,4S)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-3-(4-fluoro-2-methylphenyl)-1-[(1-glycoloylpiperidin-4-yl)carbonyl]-N-methylpiperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 945955-08-8
1-(hydroxyacetyl)piperidine-4-carboxylic acid

: 1076230-18-6
(3S,4S)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-3-(4-fluoro-2-methylphenyl)-N-methylpiperidine-4-carboxamide monohydrochloride

: 1076227-97-8
(3S,4S)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-3-(4-fluoro-2-methylphenyl)-1-[(1-glycoloylpiperidin-4-yl)carbonyl]-N-methylpiperidine-4-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In acetonitrile; at 20 ℃; for 72h;

Reference yield:

: 945955-09-9
benzyl 1-glycoloylpiperidine-4-carboxylate

: 1076227-97-8
(3S,4S)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-3-(4-fluoro-2-methylphenyl)-1-[(1-glycoloylpiperidin-4-yl)carbonyl]-N-methylpiperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 14 h / 20 °C / 760.05 Torr

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / acetonitrile / 72 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In ethanol; acetonitrile;

Reference yield:

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 1076227-97-8
(3S,4S)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-3-(4-fluoro-2-methylphenyl)-1-[(1-glycoloylpiperidin-4-yl)carbonyl]-N-methylpiperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 0 °C

2: dmap; triethylamine / tetrahydrofuran / 24 h / 0 - 20 °C

3: hydrogenchloride / ethyl acetate / 1 h / 50 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / acetonitrile / 48 h / 20 °C

5: hydrogen / palladium 10% on activated carbon / ethanol / 14 h / 20 °C / 760.05 Torr

6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / acetonitrile / 72 h / 20 °C

With hydrogenchloride; dmap; oxalyl dichloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; ethyl acetate; acetonitrile;