ethyl 4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohept-1-ene-1-carboxylate

Base Information

• Chemical Name: ethyl 4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohept-1-ene-1-carboxylate
• CAS No.: 1263677-47-9
• Molecular Formula: C₁₇H₁₇F₃O₃
• Molecular Weight: 326.315
• Mol file: 1263677-47-9.mol

Synonyms:ethyl 4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohept-1-ene-1-carboxylate

Chemical Property of ethyl 4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohept-1-ene-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohept-1-ene-1-carboxylate

There total 4 articles about ethyl 4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohept-1-ene-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-ethyl 3-methyl 4-hydroxy-2-[4-(trifluoromethyl)phenyl]cyclohepta-1,3-diene-1,3-dicarboxylate (1263677-02-6) → ethyl 4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohept-2-ene-1-carboxylate (1263677-23-1) + ethyl 4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohept-1-ene-1-carboxylate (1263677-47-9)

Guidance literature:

With hydrogenchloride; water; lithium chloride; In dimethyl sulfoxide; at 120 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol102909t

Reference yield:

1-(2,2-dibromovinyl)-4-(trifluoromethyl)benzeney (131356-53-1) → ethyl 4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohept-2-ene-1-carboxylate (1263677-23-1) + ethyl 4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohept-1-ene-1-carboxylate (1263677-47-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere

1.2: 4 h / -78 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / Inert atmosphere; Reflux

2.2: 16 h / Inert atmosphere; Reflux

3.1: hydrogenchloride; water; lithium chloride / dimethyl sulfoxide / 2 h / 120 °C / Inert atmosphere

With hydrogenchloride; n-butyllithium; water; sodium hydride; lithium chloride; In tetrahydrofuran; dimethyl sulfoxide; mineral oil; 1.1: Corey-Fuchs reaction / 1.2: Corey-Fuchs reaction;

DOI:10.1021/ol102909t

Reference yield:

methyl 3-[4-(trifluoromethyl)phenyl]prop-2-ynoate (220652-97-1) → ethyl 4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohept-2-ene-1-carboxylate (1263677-23-1) + ethyl 4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohept-1-ene-1-carboxylate (1263677-47-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / Inert atmosphere; Reflux

1.2: 16 h / Inert atmosphere; Reflux

2.1: hydrogenchloride; water; lithium chloride / dimethyl sulfoxide / 2 h / 120 °C / Inert atmosphere

With hydrogenchloride; water; sodium hydride; lithium chloride; In tetrahydrofuran; dimethyl sulfoxide; mineral oil;

DOI:10.1021/ol102909t

upstream raw materials:

methyl 3-[4-(trifluoromethyl)phenyl]prop-2-ynoate

4-Trifluoromethylbenzaldehyde

1-ethyl 3-methyl 4-hydroxy-2-[4-(trifluoromethyl)phenyl]cyclohepta-1,3-diene-1,3-dicarboxylate

1-(2,2-dibromovinyl)-4-(trifluoromethyl)benzeney