Technology Process of 1-(3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4Hchromeno[4,3-c]isoxazol-7-yl)ethane-1,2-diol
There total 15 articles about 1-(3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4Hchromeno[4,3-c]isoxazol-7-yl)ethane-1,2-diol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
at 20 ℃;
for 0.75h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C
2.1: triethylamine / 1,2-dichloro-ethane / 20 °C
3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 35 °C / sodium phosphate buffer
3.2: 20 °C
4.1: pyridine / dichloromethane / 20 °C
5.1: triethylamine / acetonitrile / 1.5 h / 0 - 20 °C
5.2: 1 h / 45 °C
6.1: thionyl chloride; pyridine / toluene / 0.5 h / 20 - 80 °C
7.1: trifluoroacetic acid / 0.75 h / 20 °C
With
pyridine; N-chloro-succinimide; thionyl chloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; triethylamine; trifluoroacetic acid;
In
dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium hydroxide / 2 h / 5 - 20 °C
1.2: 5 °C / pH 2
2.1: pyridine / 2.58 h / 0 - 20 °C
3.1: lithium chloride / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 100 °C / Sealed tube; Inert atmosphere
4.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 20 °C
5.1: (R)-10-camphorsulfonic acid / acetone / 20 °C
6.1: titanium tetrachloride / toluene / 0 - 20 °C
7.1: triethylamine / acetonitrile / 1.5 h / 0 - 20 °C
7.2: 1 h / 45 °C
8.1: thionyl chloride; pyridine / toluene / 0.5 h / 20 - 80 °C
9.1: trifluoroacetic acid / 0.75 h / 20 °C
With
pyridine; osmium(VIII) oxide; thionyl chloride; titanium tetrachloride; 4-methylmorpholine N-oxide; triethylamine; trifluoroacetic acid; lithium chloride; sodium hydroxide;
tetrakis(triphenylphosphine) palladium(0); (R)-10-camphorsulfonic acid;
In
tetrahydrofuran; 1,4-dioxane; pyridine; water; acetone; toluene; acetonitrile;
![7-(2,2-dimethyl-1,3-dioxolan-4-yl)-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[4,3-c]isoxazole](/Databaselist/images/loading.webp)
