2-(3-(4-(3-(4-fluoro-2-methylphenyl)ureido)phenyl)isoxazole-5-carboxamido)-3-methylbutanoic acid

Base Information

Chemical Name:2-(3-(4-(3-(4-fluoro-2-methylphenyl)ureido)phenyl)isoxazole-5-carboxamido)-3-methylbutanoic acid
CAS No.:1394039-26-9
Molecular Formula:C₂₃H₂₃FN₄O₅
Molecular Weight:454.458
Hs Code.:

Synonyms:2-(3-(4-(3-(4-fluoro-2-methylphenyl)ureido)phenyl)isoxazole-5-carboxamido)-3-methylbutanoic acid

Suppliers and Price of 2-(3-(4-(3-(4-fluoro-2-methylphenyl)ureido)phenyl)isoxazole-5-carboxamido)-3-methylbutanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(3-(4-(3-(4-fluoro-2-methylphenyl)ureido)phenyl)isoxazole-5-carboxamido)-3-methylbutanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(3-(4-(3-(4-fluoro-2-methylphenyl)ureido)phenyl)isoxazole-5-carboxamido)-3-methylbutanoic acid

There total 8 articles about 2-(3-(4-(3-(4-fluoro-2-methylphenyl)ureido)phenyl)isoxazole-5-carboxamido)-3-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1394039-26-9
2-(3-(4-(3-(4-fluoro-2-methylphenyl)ureido)phenyl)isoxazole-5-carboxamido)-3-methylbutanoic acid

Guidance literature:

Reference yield:

: 1287753-11-0
methyl 2-(3-(4-(3-(4-fluoro-2-methylphenyl)ureido)phenyl)isoxazole-5-carboxamido)-3-methylbutanoate

: 1394039-26-9
2-(3-(4-(3-(4-fluoro-2-methylphenyl)ureido)phenyl)isoxazole-5-carboxamido)-3-methylbutanoic acid

Guidance literature:: methyl 2-(3-(4-(3-(4-fluoro-2-methylphenyl)ureido)phenyl)isoxazole-5-carboxamido)-3-methylbutanoate; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 16h;

With hydrogenchloride; In water; pH=2;
DOI:10.1016/j.ejmech.2012.05.016

Reference yield:

: 3-(4-nitrophenyl)-5-isoxazolylcarboxylic acid

: 1394039-26-9
2-(3-(4-(3-(4-fluoro-2-methylphenyl)ureido)phenyl)isoxazole-5-carboxamido)-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h / 20 °C

1.2: -20 °C

1.3: 1.08 h / -20 - 20 °C

2.1: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 3 h / 80 °C

3.1: tetrahydrofuran / 16 h / 20 °C

4.1: lithium hydroxide / tetrahydrofuran; water / 16 h / 20 °C

4.2: pH 2

With 4-methyl-morpholine; iron; ammonium chloride; lithium hydroxide; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.ejmech.2012.05.016