5-(4-NITRO-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID ETHYL ESTER

Base Information

Chemical Name:5-(4-NITRO-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID ETHYL ESTER
CAS No.:370848-42-3
Molecular Formula:C12H10N2O5
Molecular Weight:262.222
Hs Code.:
Mol file:370848-42-3.mol

Synonyms:5-(4-NITROPHENYL)-3-ISOXAZOLECARBOXYLIC ACID ETHYL ESTER;5-(4-NITRO-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID ETHYL ESTER

Suppliers and Price of 5-(4-NITRO-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID ETHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

J&W Pharmlab
3-(4-Nitro-phenyl)-isoxazole-5-carboxylicacidethylester 97%
5g
$ 6800.00

J&W Pharmlab
3-(4-Nitro-phenyl)-isoxazole-5-carboxylicacidethylester 97%
1g
$ 1380.00

Crysdot
Ethyl3-(4-nitrophenyl)isoxazole-5-carboxylate 95+%
1g
$ 491.00

Chemenu
3-(4-Nitro-phenyl)-isoxazole-5-carboxylicacidethylester 95%
1g
$ 464.00

Total 8 raw suppliers

Chemical Property of 5-(4-NITRO-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

Boiling Point:455.8±35.0 °C(Predicted)
PKA:-6.18±0.50(Predicted)
PSA：98.15000
Density:1.331±0.06 g/cm3(Predicted)
LogP:2.94970

Purity/Quality:

99%, ^*data from raw suppliers

3-(4-Nitro-phenyl)-isoxazole-5-carboxylicacidethylester 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-(4-NITRO-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID ETHYL ESTER

There total 4 articles about 5-(4-NITRO-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 623-47-2
propynoic acid ethyl ester

: 1129-37-9,174848-02-3,20707-69-1
4-nitrobenzaldehyde oxime

: 370848-42-3
3-(4-nitro-phenyl)-isoxazol-5-carboxylic acid ethyl ester

Guidance literature:: With isopentyl nitrite; In butanone; at 65 ℃; for 3h; Reagent/catalyst; Solvent; regioselective reaction;
DOI:10.1055/s-0035-1561464

Reference yield: 88.0%

: 1011-84-3
4-nitrobenzohydroximoyl chloride

: 623-47-2
propynoic acid ethyl ester

: 370848-42-3
3-(4-nitro-phenyl)-isoxazol-5-carboxylic acid ethyl ester

Guidance literature:: With triethylamine; In toluene; at 80 ℃; for 2.5h;
DOI:10.1016/j.ejmech.2014.03.077

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 370848-42-3
3-(4-nitro-phenyl)-isoxazol-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride / methanol / 2 h / 65 °C

2: N-chloro-succinimide / N,N-dimethyl-formamide / 5 h / 20 °C

3: triethylamine / toluene / 2.5 h / 80 °C

With N-chloro-succinimide; hydroxylamine hydrochloride; triethylamine; In methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2012.05.016