Chemical Property of Nomegestrol
Chemical Property:
- Vapor Pressure:3.32E-12mmHg at 25°C
- Melting Point:204-205 °C
- Refractive Index:1.573
- Boiling Point:502.6 °C at 760 mmHg
- PKA:12.99±0.60(Predicted)
- Flash Point:271.8 °C
- PSA：54.37000
- Density:1.17g/cm3
- LogP:3.61440
- Storage Temp.:2-8°C
- XLogP3:2
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:1
- Exact Mass:328.20384475
- Heavy Atom Count:24
- Complexity:673
- Purity/Quality:
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98%,99%, *data from raw suppliers
Nomegestrol *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1=CC2C(CCC3(C2CCC3(C(=O)C)O)C)C4C1=CC(=O)CC4
- Isomeric SMILES:CC1=C[C@@H]2[C@H](CC[C@]3([C@H]2CC[C@@]3(C(=O)C)O)C)[C@@H]4C1=CC(=O)CC4
- Recent EU Clinical Trials:A phase I, single center, open-label parallel group trial to compare the pharmacokinetics of NOMAC between healthy female adolescents (aged 14-17 years) and healthy female adults (aged 18-50 years) after single dose administration of NOMAC-E2 tablets
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Description
Nomegestrol acetate is the 19-nor derivative of megestrol acetate, useful in the treatment of gynecological conditions associated with luteal deficiency. Nomegestrol is a derivative of 19-norprogesterone. It increases nuclear levels of the progesterone receptor in rat uterus when administered at a dose of 1 mg/animal.
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Uses
A progestogen, derivatives of which are used in contraceptives and hormone therapies. Progetin used in implantable hormone replacement therapies.
