N-<(1S)-(1-methoxycarbonyl-2-methylpropyl)carbamoyl>-L-valylglycyl-Ψ(CH2S)-D-leucine benzyl ester

Base Information

Chemical Name:N-<(1S)-(1-methoxycarbonyl-2-methylpropyl)carbamoyl>-L-valylglycyl-Ψ(CH2S)-D-leucine benzyl ester
CAS No.:112402-95-6
Molecular Formula:C₂₇H₄₃N₃O₆S
Molecular Weight:537.721
Hs Code.:

Synonyms:N-<(1S)-(1-methoxycarbonyl-2-methylpropyl)carbamoyl>-L-valylglycyl-Ψ(CH2S)-D-leucine benzyl ester

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Chemical Property of N-<(1S)-(1-methoxycarbonyl-2-methylpropyl)carbamoyl>-L-valylglycyl-Ψ(CH2S)-D-leucine benzyl ester

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Technology Process of N-<(1S)-(1-methoxycarbonyl-2-methylpropyl)carbamoyl>-L-valylglycyl-Ψ(CH2S)-D-leucine benzyl ester

There total 6 articles about N-<(1S)-(1-methoxycarbonyl-2-methylpropyl)carbamoyl>-L-valylglycyl-Ψ(CH2S)-D-leucine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 30293-86-8
methyl (S)-(-)-2-isocyanato-3-methylbutyrate

: Val-Gly-Ψ(CH2S)-D-Leu-OCH2Ph hydrochloride

: 112402-95-6
N-<(1S)-(1-methoxycarbonyl-2-methylpropyl)carbamoyl>-L-valylglycyl-Ψ(CH2S)-D-leucine benzyl ester

Guidance literature:: With triethylamine; In chloroform;

Reference yield:

: 61-90-5,21675-61-6,25248-98-0,70-45-1
L-leucine

: 112402-95-6
N-<(1S)-(1-methoxycarbonyl-2-methylpropyl)carbamoyl>-L-valylglycyl-Ψ(CH2S)-D-leucine benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 77 percent / sodium nitrite, potassium bromide / H₂O; H₂SO₄

2: 45 percent / 0.5 M sodium hydrogen carbonate / H₂O / 1 h

3: 79.2 percent / 1.) toluene-p-sulphonic acid monohydrate; 2.) 10 percent HCl / toluene / 2 h / Heating; 1.) Dean and Stark trap, toluene , 2 h, reflux; 2.) 10 percent HCl, water, methanol

4: 92 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodi-imide, triethylamine / dimethylformamide / 0 deg C, 1 h; r.t., overnight

5: HCl / ethyl acetate / 1 h / Ambient temperature

6: 92 percent / triethylamine / CHCl₃

With hydrogenchloride; sodium hydrogencarbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; potassium bromide; sodium nitrite; In chloroform; sulfuric acid; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 28659-87-2
(S)-2-bromo-4-methylpentanoic acid

: 112402-95-6
N-<(1S)-(1-methoxycarbonyl-2-methylpropyl)carbamoyl>-L-valylglycyl-Ψ(CH2S)-D-leucine benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 45 percent / 0.5 M sodium hydrogen carbonate / H₂O / 1 h

2: 79.2 percent / 1.) toluene-p-sulphonic acid monohydrate; 2.) 10 percent HCl / toluene / 2 h / Heating; 1.) Dean and Stark trap, toluene , 2 h, reflux; 2.) 10 percent HCl, water, methanol

3: 92 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodi-imide, triethylamine / dimethylformamide / 0 deg C, 1 h; r.t., overnight

4: HCl / ethyl acetate / 1 h / Ambient temperature

5: 92 percent / triethylamine / CHCl₃

With hydrogenchloride; sodium hydrogencarbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; In chloroform; water; ethyl acetate; N,N-dimethyl-formamide; toluene;