S-2--Bromo -4-methylvaleric acid

Base Information

• Chemical Name: S-2--Bromo -4-methylvaleric acid
• CAS No.: 28659-87-2
• Molecular Formula: C6H11BrO2
• Molecular Weight: 195.056
• Hs Code.: 2915900090
• Mol file: 28659-87-2.mol

Synonyms:Pentanoicacid, 2-bromo-4-methyl-, (S)-;Valeric acid, 2-bromo-4-methyl-, (S)- (8CI);(S)-2-Bromo-4-methylpentanoic acid;L-a-Bromo-g-methylvaleric acid;L-a-Bromoisocaproic acid;S-2-Bromo-4-methylvaleric acid;

Chemical Property of S-2--Bromo -4-methylvaleric acid

Chemical Property:

• Vapor Pressure: 0.0126mmHg at 25°C
• Refractive Index: 1.485
• Boiling Point: 240.5 °C at 760 mmHg
• Flash Point: 99.3 °C
• PSA: 37.30000
• Density: 1.432 g/cm³
• LogP: 1.88060
• Storage Temp.: 2-8°C

Purity/Quality:

99.99%HPLC ^*data from raw suppliers

(S)-2-Bromo-4-methylpentanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of S-2--Bromo -4-methylvaleric acid

There total 19 articles about S-2--Bromo -4-methylvaleric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → (S)-2-bromo-4-methylpentanoic acid (28659-87-2)

Guidance literature:

With hydrogen bromide; sodium nitrite; at 0 - 20 ℃;

DOI:10.1016/j.bioorg.2021.105158

Reference yield: 81.0%

→ (S)-2-bromo-4-methylpentanoic acid (28659-87-2)

Guidance literature:

Reference yield: 65.0%

LEUCINE (328-39-2,21675-61-6,25248-98-0,70-45-1) → 2-Bromo-4-methylpentanoic Acid (28659-87-2,42990-28-3,49628-52-6,42990-24-9)

Guidance literature:

With hydrogen bromide; sodium nitrite;

DOI:10.1021/jm00156a012

upstream raw materials:

L-leucine

N-formyl-valine

4-Methylpentanoic acid

LEUCINE

Downstream raw materials:

N-phenyl-DL-leucine

2-(benzyloxyamino)-4-methylpentanoic acid

(R)-leucine

L-leucine

Refernces

• 1、 Barabanov, A. A.,Bukatov, G. D.,Mainagashev, I. Ya.,Mats’ko, M. A.,Nechepurenko, I. V.,Salakhutdinov, N. F.,Sergeev, S. A.,Volcho, K. P.,Zakharov, V. A.. "A New Approach to the Synthesis of Diethyl 2,3-Diisobutylsuccinate, a Component of Titanium–Magnesium Catalysts for Propylene Polymerization". . p. 715 - 725. Retrieved 2021/08/13.
• 2、 Aitken, R. Alan,Lightfoot, Philip,Thomas, Andrew W.. "Synthesis, structure and reactivity of some chiral benzylthio alcohols, 1,3-oxathiolanes and their S-oxides". . p. 369 - 387. Retrieved 2020/05/25.