(S)-2-(4-Fluoro-phenyl)-pent-4-enoic acid 3,5-bis-trifluoromethyl-benzylamide

Base Information

Chemical Name:(S)-2-(4-Fluoro-phenyl)-pent-4-enoic acid 3,5-bis-trifluoromethyl-benzylamide
CAS No.:691875-76-0
Molecular Formula:C₂₀H₁₆F₇NO
Molecular Weight:419.342
Hs Code.:

Synonyms:(S)-2-(4-Fluoro-phenyl)-pent-4-enoic acid 3,5-bis-trifluoromethyl-benzylamide

Suppliers and Price of (S)-2-(4-Fluoro-phenyl)-pent-4-enoic acid 3,5-bis-trifluoromethyl-benzylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-(4-Fluoro-phenyl)-pent-4-enoic acid 3,5-bis-trifluoromethyl-benzylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-(4-Fluoro-phenyl)-pent-4-enoic acid 3,5-bis-trifluoromethyl-benzylamide

There total 3 articles about (S)-2-(4-Fluoro-phenyl)-pent-4-enoic acid 3,5-bis-trifluoromethyl-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 85068-29-7
3,5-bis-trifluoromethylbenzylamine

: 494802-92-5
(S)-2-(4-fluorophenyl)-4-pentenoic acid

: 691875-76-0
(S)-2-(4-Fluoro-phenyl)-pent-4-enoic acid 3,5-bis-trifluoromethyl-benzylamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

Reference yield:

: 51230-93-4
2-(4-fluorophenyl)pent-4-enoic acid

: 691875-76-0
(S)-2-(4-Fluoro-phenyl)-pent-4-enoic acid 3,5-bis-trifluoromethyl-benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1: (S)-(-)-α-methylbenzylamine / ethyl acetate

2: 9.41 g / EDC; HOBt / CH₂Cl₂ / 20 °C

With (S)-1-phenyl-ethylamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; ethyl acetate;
DOI:10.1021/jm060439n

Reference yield:

: 405-50-5
p-Fluorophenylacetic acid

: 691875-76-0
(S)-2-(4-Fluoro-phenyl)-pent-4-enoic acid 3,5-bis-trifluoromethyl-benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: LHMDS / tetrahydrofuran / 2.25 h / -15 °C

1.2: tetrahydrofuran / -15 - 20 °C

2.1: (S)-(-)-α-methylbenzylamine / ethyl acetate

3.1: 9.41 g / EDC; HOBt / CH₂Cl₂ / 20 °C

With (S)-1-phenyl-ethylamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/jm060439n