494802-92-5

Upstream product

• 459-04-1 4-Fluorophenylacetyl chloride 
• 159707-16-1 (4S)-benzyl-3-[2'-(4-fluorophenyl)acetyl]-2-oxazolidinone 
• 405-50-5 p-Fluorophenylacetic acid 
• 51230-93-4 2-(4-fluorophenyl)pent-4-enoic acid 

Downstream Products

• 810680-77-4 (S)-2-(4-fluorophenyl)pent-4-enoyl chloride 
• 209349-07-5 1'-(3-((S)-(4-Fluorophenyl))-4-(N-(phenylsulfonyl)(methylamino))butyl)-spiro(2,3-dihydrobenzothiophene-3,4'-piperidine) 
• 334824-79-2 N-[2-(4-fluoro-phenyl)-pent-4-enyl]-N-methyl-benzenesulfonamide 
• 334824-88-3 N-[2-(4-fluoro-phenyl)-4-oxo-butyl]-N-methyl-benzenesulfonamide 
• 235097-94-6 (S)-2-(4-fluorophenyl)pent-4-enoic acid,N-methyl amide 
• 235097-95-7 [(2S)-2-(4-fluorophenyl)pent-4-en-1-yl]methylamine 
• 691873-56-0 N-(3,5-bis-trifluoromethyl-benzyl)-2-(4-fluoro-phenyl)-4-(4-phenyl-piperidin-1-yl)-butyramide 

Relevant academic research and scientific papers

Novel, orally bioavailable γ-aminoamide CC chemokine receptor 2 (CCR2) antagonists

Through modification of a screening hit we have discovered a structurally distinct new lead, (2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-(4-fluorophenyl)-4- (4-phenylpiperidin-1-yl)butanamide (11), which has subsequently served as the departure point for an

GAMMA-AMINOAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The present invention is directed to compounds of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R11, R12, W, X, and n are defined herein, which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.

Synthesis of enantiomerically enriched (S)-(+)-2-aryl-4-pentenoic acids and (R)-(-)-2-aryl-4-pentenamides via microbial hydrolysis of nitriles, a chemoenzymatic approach to stereoisomers of α,γ-disubstituted γ-butyrolactones

In the presence of the nitrile hydratase/amidase-containing Rhodococcus sp. AJ270 whole cell catalyst, 2-aryl-4-pentenenitriles 1 underwent enantioselective hydrolysis under mild conditions to afford (R)-(-)-2-aryl-4-pentenoic acid amides 2 and (S)-(+)-2-

Highly enantioselective biotransformations of 2-aryl-4-pentenenitriles, a novel chemoenzymatic approach to (R)-(-)-baclofen

Catalyzed by Rhodococcus sp. AJ270 microbial cells under mild conditions, a range of racemic 2-aryl-4-pentenenitriles 1 underwent effective hydrolysis to afford excellent yields of enantiomerically pure (R)-(-)-2-aryl-4-pentenamides 2 and (S)-(+)-2-aryl-4-pentenoic acids 3 in most cases. The application of this biotransformation has been shown by a two-step synthesis of (R)-(-)-baclofen.