3-chloro-5-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol

Base Information

Chemical Name:3-chloro-5-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol
CAS No.:1509919-70-3
Molecular Formula:C₁₉H₁₅ClN₄O₃
Molecular Weight:382.806
Hs Code.:

Synonyms:3-chloro-5-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol

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Chemical Property of 3-chloro-5-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol

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Technology Process of 3-chloro-5-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol

There total 9 articles about 3-chloro-5-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.5%

: 1509919-98-5
2-(3-chloro-5-methoxyphenyl)-4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidine

: 1509919-70-3
3-chloro-5-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol

Guidance literature:: With water; hydrogen bromide; In acetic acid; at 80 ℃; for 48h;
DOI:10.1021/ml400378e

Reference yield:

: 1509919-84-9
3-(3-chloro-5-methoxybenzamido)furo[2,3-b]pyridine-2-carboxamide

: 1509919-70-3
3-chloro-5-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / isopropyl alcohol / 4 h / Reflux

2: trichlorophosphate / 4 h / 110 °C / Cooling with ice

3: toluene / 4 h / 0 - 135 °C

4: hydrogen bromide; water / acetic acid / 48 h / 80 °C

With water; hydrogen bromide; sodium hydroxide; trichlorophosphate; In acetic acid; isopropyl alcohol; toluene;
DOI:10.1021/ml400378e

Reference yield:

: 6602-54-6
2-chloro-3-pyridinecarbonitrile

: 1509919-70-3
3-chloro-5-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol

Guidance literature:: Multi-step reaction with 7 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 75 °C

2: pyridine / tetrahydrofuran / 0 - 20 °C

3: ammonium hydroxide / methanol / 6 h / 50 °C

4: sodium hydroxide / isopropyl alcohol / 4 h / Reflux

5: trichlorophosphate / 4 h / 110 °C / Cooling with ice

6: toluene / 4 h / 0 - 135 °C

7: hydrogen bromide; water / acetic acid / 48 h / 80 °C

With pyridine; ammonium hydroxide; water; hydrogen bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; acetic acid; isopropyl alcohol; toluene;
DOI:10.1021/ml400378e