Oxalic acid 1-[(3S,5S)-5-((S)-1-tert-butoxycarbonylamino-2-cyclohexyl-ethyl)-2-oxo-tetrahydro-furan-3-yl]-1-methyl-ethyl ester methyl ester

Base Information

Chemical Name:Oxalic acid 1-[(3S,5S)-5-((S)-1-tert-butoxycarbonylamino-2-cyclohexyl-ethyl)-2-oxo-tetrahydro-furan-3-yl]-1-methyl-ethyl ester methyl ester
CAS No.:127772-94-5
Molecular Formula:C₂₃H₃₇NO₈
Molecular Weight:455.549
Hs Code.:

Synonyms:Oxalic acid 1-[(3S,5S)-5-((S)-1-tert-butoxycarbonylamino-2-cyclohexyl-ethyl)-2-oxo-tetrahydro-furan-3-yl]-1-methyl-ethyl ester methyl ester

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Chemical Property of Oxalic acid 1-[(3S,5S)-5-((S)-1-tert-butoxycarbonylamino-2-cyclohexyl-ethyl)-2-oxo-tetrahydro-furan-3-yl]-1-methyl-ethyl ester methyl ester

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Technology Process of Oxalic acid 1-[(3S,5S)-5-((S)-1-tert-butoxycarbonylamino-2-cyclohexyl-ethyl)-2-oxo-tetrahydro-furan-3-yl]-1-methyl-ethyl ester methyl ester

There total 6 articles about Oxalic acid 1-[(3S,5S)-5-((S)-1-tert-butoxycarbonylamino-2-cyclohexyl-ethyl)-2-oxo-tetrahydro-furan-3-yl]-1-methyl-ethyl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 5781-53-3
monomethyl oxalyl chloride

: 125015-95-4
(3S,5S)-5-[(1S)-1-(N-t-butoxycarbonylamino)-2-cyclohexylethyl]-3-(1-hydroxy-1-methylethyl)dihydrofuran-2(3H)-one

: 127772-94-5
Oxalic acid 1-[(3S,5S)-5-((S)-1-tert-butoxycarbonylamino-2-cyclohexyl-ethyl)-2-oxo-tetrahydro-furan-3-yl]-1-methyl-ethyl ester methyl ester

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 0 ℃;

Reference yield:

: 98105-42-1
(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

: 127772-94-5
Oxalic acid 1-[(3S,5S)-5-((S)-1-tert-butoxycarbonylamino-2-cyclohexyl-ethyl)-2-oxo-tetrahydro-furan-3-yl]-1-methyl-ethyl ester methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / -78 °C

2: H₂ / Pd/BaSO₄ / ethyl acetate / 3040 Torr

3: PCC, molecular sieves (3 Angstroem) / CH₂Cl₂

4: 1.) KBH₄, 2.) HOAc / 1.) ethanol, 0 deg C, 6 h, 2.) toluene, reflux

5: 1) LDA / 2) THF, -78 deg C

6: 99 percent / NEt₃, DMAP / tetrahydrofuran / 0 °C

With dmap; potassium borohydride; 3 A molecular sieve; hydrogen; acetic acid; triethylamine; pyridinium chlorochromate; lithium diisopropyl amide; Pd-BaSO₄; In tetrahydrofuran; dichloromethane; ethyl acetate;

Reference yield:

: (S)-5-tert-Butoxycarbonylamino-6-cyclohexyl-4-hydroxy-hex-2-ynoic acid ethyl ester

: 127772-94-5
Oxalic acid 1-[(3S,5S)-5-((S)-1-tert-butoxycarbonylamino-2-cyclohexyl-ethyl)-2-oxo-tetrahydro-furan-3-yl]-1-methyl-ethyl ester methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/BaSO₄ / ethyl acetate / 3040 Torr

2: PCC, molecular sieves (3 Angstroem) / CH₂Cl₂

3: 1.) KBH₄, 2.) HOAc / 1.) ethanol, 0 deg C, 6 h, 2.) toluene, reflux

4: 1) LDA / 2) THF, -78 deg C

5: 99 percent / NEt₃, DMAP / tetrahydrofuran / 0 °C

With dmap; potassium borohydride; 3 A molecular sieve; hydrogen; acetic acid; triethylamine; pyridinium chlorochromate; lithium diisopropyl amide; Pd-BaSO₄; In tetrahydrofuran; dichloromethane; ethyl acetate;