125015-95-4

Upstream product

• 112227-09-5 (5S)-5-[(1S)-1-(N-t-butoxycarbonylamino)-2-cyclohexylethyl]dihydrofuran-2(3H)-one 
• 67-64-1 acetone 
• 127772-89-8 (S)-5-tert-Butoxycarbonylamino-6-cyclohexyl-4-oxo-hexanoic acid ethyl ester 
• 98105-42-1 (S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal 

Downstream Products

• 127772-94-5 Oxalic acid 1-[(3S,5S)-5-((S)-1-tert-butoxycarbonylamino-2-cyclohexyl-ethyl)-2-oxo-tetrahydro-furan-3-yl]-1-methyl-ethyl ester methyl ester 
• 125015-96-5 (2S,4S,5S)-5-(t-butoxycarbonylamino)-6-cyclohexyl-4-hydroxy-2-(1-hydroxy-1-methylethyl)-N-[2(S)-methylbutyl]hexanamide 
• 125016-07-1 (2S,4S,5S)-5-(t-butoxycarbonylamino)-6-cyclohexyl-4-hydroxy-2-(1-hydroxy-1-methylethyl)-N-methylhexanamide 
• 125016-12-8 (2S,4S,5S)-5-(t-butoxycarbonylamino)-6-cyclohexyl-4-hydroxy-2-(1-hydroxy-1-methylethyl)-N-butylhexanamide 
• 124032-36-6 (3S,5S)-5-[(1S)-1-(t-butoxycarbonyl)amino-2-cyclohexylethyl]-3-isopropyldihydrofuran-2(3H)-one 
• 123580-22-3 [(S)-2-Cyclohexyl-1-((2S,4R)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester 
• 127772-92-3 [(S)-2-Cyclohexyl-1-((S)-4-isopropylidene-5-oxo-tetrahydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

RENIN-INHIBITORY OLIGOPEPTIDES, THEIR PREPARATION AND USE

Compounds of formula (I): STR1 A is a carbon-carbon bond or C 1-C 3 alkylene; B is imino group or C 1-C 2 alkylene; R 1 is C 1-C 4 alkyl, C 1-C 4 alkoxy, heterocyclic or optionally substituted amino; R 2 is optionally substituted phenyl or optionally substituted naphthyl; R 3 is thiazolyl, isoxazolyl or imidazolyl; R 4 is isopropyl or cyclohexyl; R 5 and R 6 are C. sub.1-C 4 alkyl, or, together with the carbon atom to which they are attached, C 3-C 7 cycloalkyl; R. sup.7 is hydrogen, optionally substituted C 1-C 6 alkyl group; and R 8 is hydrogen or C. sub.1-C 4 alkyl. These compounds have renin-inhibitory and, hence, hypotensive activities. The invention also provides a method for the treatment or prophylaxis of hypertension induced by failures in the renin-angiotensin system.

Diastereoselective Synthesis of the Hydroxyethylene Dipeptide Isostere of Leu-Val

The synthesis of hydroxyethylene dipeptide isostere of Leu-Val, a transition-state mimic, is described.The key steps of this synthetic approach are the homogeneous asymmetric hydrogenation of γ-keto esters by BINAP-Ru(II) complex, and the construction of