(4-(((tert-butyldimethylsilyl)oxy)methyl)-2,6-dichlorophenyl)(4-chlorophenyl)methanone

Base Information

Chemical Name:(4-(((tert-butyldimethylsilyl)oxy)methyl)-2,6-dichlorophenyl)(4-chlorophenyl)methanone
CAS No.:99520-09-9
Molecular Formula:C₂₀H₂₃Cl₃O₂Si
Molecular Weight:429.846
Hs Code.:

Synonyms:(4-(((tert-butyldimethylsilyl)oxy)methyl)-2,6-dichlorophenyl)(4-chlorophenyl)methanone

Suppliers and Price of (4-(((tert-butyldimethylsilyl)oxy)methyl)-2,6-dichlorophenyl)(4-chlorophenyl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4-(((tert-butyldimethylsilyl)oxy)methyl)-2,6-dichlorophenyl)(4-chlorophenyl)methanone

Chemical Property:

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Technology Process of (4-(((tert-butyldimethylsilyl)oxy)methyl)-2,6-dichlorophenyl)(4-chlorophenyl)methanone

There total 5 articles about (4-(((tert-butyldimethylsilyl)oxy)methyl)-2,6-dichlorophenyl)(4-chlorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60211-57-6
3,5-dichlorobenzyl alcohol

: 99520-09-9
(4-(((tert-butyldimethylsilyl)oxy)methyl)-2,6-dichlorophenyl)(4-chlorophenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 24 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / -72 - -60 °C

2.2: 3 h / -60 °C

With 1H-imidazole; dmap; n-butyllithium; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.7554/eLife.55845

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 99520-09-9
(4-(((tert-butyldimethylsilyl)oxy)methyl)-2,6-dichlorophenyl)(4-chlorophenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 24 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / -72 - -60 °C

2.2: 3 h / -60 °C

With 1H-imidazole; dmap; n-butyllithium; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.7554/eLife.55845

Reference yield:

: 2905-62-6
3,5-dichlorobenzoyl chloride

: 99520-09-9
(4-(((tert-butyldimethylsilyl)oxy)methyl)-2,6-dichlorophenyl)(4-chlorophenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc(II) chloride; potassium borohydride / tetrahydrofuran / 5 h / 45 °C / Large scale

2.1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 5 h / 0 - 30 °C / Inert atmosphere; Large scale

3.1: n-butyllithium / tetrahydrofuran / 0.75 h / -80 - -65 °C / Inert atmosphere; Large scale

3.2: 4.5 h / -75 - -65 °C / Large scale

With 1H-imidazole; dmap; n-butyllithium; potassium borohydride; zinc(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide;